Human LYPLA2 Recombinant Protein (RPPB1916)
- SKU:
- RPPB1916
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- LYPLA2
- Synonyms:
- Acyl-protein thioesterase 2
- APT-2
- Lysophospholipase II
- LPL-II
- Source:
- Escherichia Coli
- Uniprot:
- O95372
Description
| Product Name: | Human LYPLA2 Recombinant Protein |
| Product Code: | RPPB1916 |
| Size: | 20µg |
| Species: | Human |
| Target: | LYPLA2 |
| Synonyms: | Acyl-protein thioesterase 2, APT-2, Lysophospholipase II, LPL-II, LysoPLA II, LYPLA2, APT2, DJ886K2.4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LYPLA2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V |
Acyl-protein thioesterase 2 (LYPLA2) is lysophospholipase which acts on biological membranes to regulate the multifunctional lysophospholipids. LYPLA2 may hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS.
LYPLA2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 251 amino acids (1-231 a.a.) and having a molecular mass of 26.9kDa. The LYPLA2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LYPLA2: May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity. Deacylates GAP43. Belongs to the AB hydrolase 2 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerophospholipid; EC 3.1.2.-; Phospholipase Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: cytoplasm Molecular Function:palmitoyl-(protein) hydrolase activity Biological Process: protein depalmitoylation |
| NCBI Summary: | Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95372 |
| NCBI GenInfo Identifier: | 41017276 |
| NCBI Gene ID: | 11313 |
| NCBI Accession: | O95372.1 |
| UniProt Secondary Accession: | O95372,Q7Z4Z2, |
| UniProt Related Accession: | O95372 |
| Molecular Weight: | 24,737 Da |
| NCBI Full Name: | Acyl-protein thioesterase 2 |
| NCBI Synonym Full Names: | lysophospholipase II |
| NCBI Official Symbol: | LYPLA2 |
| NCBI Official Synonym Symbols: | APT2; APT-2; DJ886K2.4 |
| NCBI Protein Information: | acyl-protein thioesterase 2 |
| UniProt Protein Name: | Acyl-protein thioesterase 2 |
| UniProt Synonym Protein Names: | Lysophospholipase II; LPL-II; LysoPLA II |
| Protein Family: | Acyl-protein thioesterase |
| UniProt Gene Name: | LYPLA2 |
| UniProt Entry Name: | LYPA2_HUMAN |
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