Human LUM Recombinant Protein (RPPB3889)
- SKU:
- RPPB3889
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- LUM
- Synonyms:
- Lumican
- LDC
- Lumican Proteoglycan
- Keratan Sulfate Proteoglycan Lumican
- Source:
- Sf9 Insect cells
- Uniprot:
- P51884
Description
| Product Name: | Human LUM Recombinant Protein |
| Product Code: | RPPB3889 |
| Size: | 10µg |
| Species: | Human |
| Target: | LUM |
| Synonyms: | Lumican, LDC, Lumican Proteoglycan, Keratan Sulfate Proteoglycan Lumican, SLRR2D, KSPG Lumican. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LUM protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLQYYDYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLNHHHHHH |
Lumican also known as LUM belongs to the small leucine-rich proteoglycan (SLRP) family which comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Furthermore we can see that in these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagen fibril organization and circumferential growth, corneal transparency, epithelial cell migration and tissue repair. Among the diseases associated with LUM is posterior amorphous corneal dystrophy.
LUM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 329 amino acids (19-338 aa) and having a molecular mass of 37.7kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).LUM is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q21.33 Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix Molecular Function:collagen binding; protein binding Biological Process: axonogenesis; extracellular matrix organization and biogenesis; keratan sulfate biosynthetic process; keratan sulfate catabolic process |
| NCBI Summary: | This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51884 |
| NCBI GenInfo Identifier: | 20141464 |
| NCBI Gene ID: | 4060 |
| NCBI Accession: | P51884.2 |
| UniProt Secondary Accession: | P51884,Q96QM7, B2R6R5, |
| UniProt Related Accession: | P51884 |
| Molecular Weight: | 38,429 Da |
| NCBI Full Name: | Lumican |
| NCBI Synonym Full Names: | lumican |
| NCBI Official Symbol: | LUM |
| NCBI Official Synonym Symbols: | LDC; SLRR2D |
| NCBI Protein Information: | lumican |
| UniProt Protein Name: | Lumican |
| UniProt Synonym Protein Names: | Keratan sulfate proteoglycan lumican; KSPG lumican |
| Protein Family: | Lumican |
| UniProt Gene Name: | LUM |
| UniProt Entry Name: | LUM_HUMAN |
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