Human LSM2 Recombinant Protein (RPPB3883)

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SKU:
RPPB3883
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
LSM2
Synonyms:
LSM2 homolog U6 small nuclear RNA associated (S cerevisiae)
Synonyms:
Small nuclear ribonuclear protein D homolog
Synonyms:
chromosome 6 open reading frame 28
Synonyms:
snRNP core Sm-like protein Sm-x5
Source:
Escherichia Coli
Uniprot:
Q9Y333
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Description

Product Name:Human LSM2 Recombinant Protein
Product Code:RPPB3883
Size:20µg
Species:Human
Target:LSM2
Synonyms:LSM2 homolog U6 small nuclear RNA associated (S. cerevisiae), Small nuclear ribonuclear protein D homolog, chromosome 6 open reading frame 28, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W, Protein G7b, snRNP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LSM2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM Nacl, 5mM DTT and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMLFYSF FKSLVGKDVV VELKNDLSIC GTLHSVDQYL NIKLTDISVT DPEKYPHMLS VKNCFIRGSV VRYVQLPADE VDTQLLQDAA RKEALQQKQ

LSM2 is a member of the snRNP Sm proteins family. Sm-like proteins are branded in several organisms based on sequence homology with the Sm protein family. Sm-like proteins hold the Sm sequence motif that is made up of 2 regions separated by a linker of variable length which folds as a loop. The Sm-like proteins are believed to create a steady heteromer present in tri-snRNP particles, which are vital for pre-mRNA splicing. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA nad takes part in pre-mRNA splicing.

LSM2 Human Recombinant produced in E. coli is a single polypeptide chain containing 119 amino acids (1-95) and having a molecular mass of 13.4kDa.LSM2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LSM2: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol; nucleoplasm; U4/U6 x U5 tri-snRNP complex

Molecular Function:protein binding; Ral GTPase binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
UniProt Code:Q9Y333
NCBI GenInfo Identifier:10720079
NCBI Gene ID:57819
NCBI Accession:Q9Y333.1
UniProt Secondary Accession:Q9Y333,Q6FGG1,
UniProt Related Accession:Q9Y333
Molecular Weight:10,835 Da
NCBI Full Name:U6 snRNA-associated Sm-like protein LSm2
NCBI Synonym Full Names:LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
NCBI Official Symbol:LSM2  
NCBI Official Synonym Symbols:G7B; snRNP; C6orf28; YBL026W  
NCBI Protein Information:U6 snRNA-associated Sm-like protein LSm2
UniProt Protein Name:U6 snRNA-associated Sm-like protein LSm2
UniProt Synonym Protein Names:Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP core Sm-like protein Sm-x5
Protein Family:Sm-like protein
UniProt Gene Name:LSM2  
UniProt Entry Name:LSM2_HUMAN
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