The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions; also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule; serving as a guidance cue for specific patterns of connectivity; which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety; indicating a possible role of LsAMP in the regulation of anxiety.
Product Name:
Human LSAMP Recombinant Protein (RPES3516)
Product Code:
RPES3516
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
FLJ34254,FLJ35396,FLJ37216,FLJ54658,IGLON3,LAMP
Accession:
Q13449
Sequence:
Met 1-Asn 315
Fusion tag:
C-Fc
Activity:
Measured by its binding ability in a functional ELISA.Immobilized recombinant human OPCML-His at 10 µg/mL can bind recombinant human LSAMP-Fc with a linear range of 31.25-250 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315); without the pro peptide; was was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
59 kDa
AP Mol Mass:
80-85 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
