Human LRPAP1 Recombinant Protein (RPPB3874)
- SKU:
- RPPB3874
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- LRPAP1
- Synonyms:
- Low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
- A2MRAP
- HBP44
- RAP
- Source:
- Escherichia Coli
- Uniprot:
- P30533
Description
| Product Name: | Human LRPAP1 Recombinant Protein |
| Product Code: | RPPB3874 |
| Size: | 20µg |
| Species: | Human |
| Target: | LRPAP1 |
| Synonyms: | Low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1), A2MRAP, HBP44, RAP, A2RAP, Alpha-2-MRAP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LRPAP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMYSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRL HLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI HENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANL TDKELEAFRE ELKHFEAKIE KHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL |
LRPAP1 is a member of the alpha-2-MRAP family. LRPAP1 cooperates with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. LRPAP1, located on the cell surface, creates a complex with the alpha 2 macroglobulin receptor light and heavy chains and has part in the pathogenesis of membrane glomerular nephritis.
LRPAP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (35-357) and having a molecular mass of 40.4kDa.LRPAP1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. |
| UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle Molecular Function:heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding Disease: Myopia 23, Autosomal Recessive |
| NCBI Summary: | This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P30533 |
| NCBI GenInfo Identifier: | 231539 |
| NCBI Gene ID: | 4043 |
| NCBI Accession: | P30533.1 |
| UniProt Related Accession: | P30533 |
| Molecular Weight: | |
| NCBI Full Name: | Alpha-2-macroglobulin receptor-associated protein |
| NCBI Synonym Full Names: | LDL receptor related protein associated protein 1 |
| NCBI Official Symbol: | LRPAP1 |
| NCBI Official Synonym Symbols: | RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP |
| NCBI Protein Information: | alpha-2-macroglobulin receptor-associated protein |
| UniProt Protein Name: | Alpha-2-macroglobulin receptor-associated protein |
| UniProt Synonym Protein Names: | Low density lipoprotein receptor-related protein-associated protein 1; RAP |
| UniProt Gene Name: | LRPAP1 |
| UniProt Entry Name: | AMRP_HUMAN |
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