Human LGALS8 Recombinant Protein (RPPB0288)
- SKU:
- RPPB0288
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- LGALS8
- Synonyms:
- Gal-8
- PCTA1
- Po66-CBP
- Prostate carcinoma tumor antigen 1
- Source:
- Escherichia Coli
- Uniprot:
- O00214
Description
| Product Name: | Human LGALS8 Recombinant Protein |
| Product Code: | RPPB0288 |
| Size: | 10µg |
| Species: | Human |
| Target: | LGALS8 |
| Synonyms: | Gal-8, PCTA1, Po66-CBP, Prostate carcinoma tumor antigen 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Galectin-8 His tag 0.5mg/ml protein solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 10% glycerol & 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MMLSLNNLQN IIYNPVIPFV GTIPDQLDPG TLIVIRGHVP SDADRFQVDL QNGSSMKPRA DVAFHFNPRF KRAGCIVCNT LINEKWGREE ITYDTPFKRE KSFEIVIMVL KDKFQVAVNG KHTLLYGHRI GPEKIDTLGI YGKVNIHSIG FSFSSDLQST QASSLELTEI SRENVPKSGT PQLRLPFAAR LNTPMGPGRT VVVKGEVNAN AKSFNVDLLA GKSKDIALHL NPRLNIKAFV RNSFLQESWG EEERNITSFP FSPGMYFEMI IYCDVREFKV AVNGVHSLEY KHRFKELSSI DTLEINGDIH LLEVRSW |
| Biological Activity: | The ED50 for this effect is 5–10ug/ml. Measured by its ability to agglutinate human red blood cells corresponding to a specific activity of 100-200IU/mg. |
LGALS8 is a prostate-specific antigen that is solely overexpressed in malignant tumors and thus is a supplementary specific identifier of malignancies. LGALS8 is part of the galectin gene family which facilitates both cell-cell and cell matrix interactions in a method parallel to the selectin subgroup of C-type lectins.
LGALS8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37.9 kDa. The LGALS8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | galectin-8: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 1q43 Cellular Component: cytosol; extracellular space; membrane Molecular Function:carbohydrate binding; protein binding |
| NCBI Summary: | This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00214 |
| NCBI GenInfo Identifier: | 292495094 |
| NCBI Gene ID: | 3964 |
| NCBI Accession: | O00214.4 |
| UniProt Secondary Accession: | O00214,O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8 Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, |
| UniProt Related Accession: | O00214 |
| Molecular Weight: | 40,397 Da |
| NCBI Full Name: | Galectin-8 |
| NCBI Synonym Full Names: | galectin 8 |
| NCBI Official Symbol: | LGALS8 |
| NCBI Official Synonym Symbols: | Gal-8; PCTA1; PCTA-1; Po66-CBP |
| NCBI Protein Information: | galectin-8 |
| UniProt Protein Name: | Galectin-8 |
| UniProt Synonym Protein Names: | Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1; PCTA-1 |
| Protein Family: | Galectin |
| UniProt Gene Name: | LGALS8 |
| UniProt Entry Name: | LEG8_HUMAN |
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