Human LGALS2 Recombinant Protein (RPPB0275)

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SKU:
RPPB0275
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
LGALS2
Synonyms:
HL14
Synonyms:
Gal-2
Synonyms:
Beta-galactoside-binding lectin L-14-II
Synonyms:
Lactose-binding lectin 2
Source:
Escherichia Coli
Uniprot:
P05162
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Description

Product Name:Human LGALS2 Recombinant Protein
Product Code:RPPB0275
Size:25µg
Species:Human
Target:LGALS2
Synonyms:HL14, Gal-2, Beta-galactoside-binding lectin L-14-II, Lactose-binding lectin 2, S-Lac lectin 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The Galectin-2 His tag 0.5mg/ml protein solution contains 20mM Tris-HCl pH-8, 0.2M NaCl, 10% glycerol & 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF SESTIVCNSL DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG HELTFPNRLG HSHLSYLSVR GGFNMSSFKL KE

LGALS2 is a soluble beta-galactoside binding lectin that controls cell-to-cell adhesion and cell-to-extracellular matrix interactions and takes part in tumor progression, pre-mRNA splicing and apoptosis. LGALS2 induces apoptosis in activated T cells and binds to the cytokine lymphotoxin-alpha (LTA) with threat of myocardial infarction.

LGALS2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 152 amino acids (1-132 a.a.) and having a molecular mass of 16.8 kDa. The LGALS2 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:LGALS2: This protein binds beta-galactoside. Its physiological function is not yet known.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 22q13.1

Molecular Function:galactoside binding; carbohydrate binding

Disease: Myocardial Infarction, Susceptibility To

NCBI Summary:The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
UniProt Code:P05162
NCBI GenInfo Identifier:585388
NCBI Gene ID:3957
NCBI Accession:P05162.3
UniProt Secondary Accession:P05162,Q6FGY4,
UniProt Related Accession:P05162
Molecular Weight:132
NCBI Full Name:Galectin-2
NCBI Synonym Full Names:lectin, galactoside-binding, soluble, 2
NCBI Official Symbol:LGALS2  
NCBI Official Synonym Symbols:HL14  
NCBI Protein Information:galectin-2; gal-2; galectin 2; S-Lac lectin 2; lactose-binding lectin 2; beta-galactoside-binding lectin L-14-II
UniProt Protein Name:Galectin-2
UniProt Synonym Protein Names:Beta-galactoside-binding lectin L-14-II; HL14; Lactose-binding lectin 2; S-Lac lectin 2
UniProt Gene Name:LGALS2  
UniProt Entry Name:LEG2_HUMAN
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