Human LGALS10 Recombinant Protein (RPPB3857)
- SKU:
- RPPB3857
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- LGALS10
- Synonyms:
- Eosinophil lysophospholipase
- Charcot-Leyden crystal protein
- CLC
- Galectin-10
- Source:
- Escherichia Coli
- Uniprot:
- Q05315
Description
| Product Name: | Human LGALS10 Recombinant Protein |
| Product Code: | RPPB3857 |
| Size: | 20µg |
| Species: | Human |
| Target: | LGALS10 |
| Synonyms: | Eosinophil lysophospholipase, Charcot-Leyden crystal protein, CLC, Galectin-10, Gal-10, Lysolecithin acylhydrolase, GAL10, LGALS10, LGALS10A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | Galectin-10 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI VFHFQVCFGR RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY QVMVNGQSSY TFDHRIKPEA VKMVQVWRDI SLTKFNVSYL KR |
Eosinophil lysophospholipase (CLC) acts on biological membranes to regulate the multifunctional lysophospholipids. CLC is a lysophospholipase expressed in eosinophils and basophils. CLC hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. The CLC protein may possess carbohydrate or IgE-binding activities. CLC is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. CLC may be linked with inflammation and some myeloid leukemias.
LGALS10 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 162 amino acids (1-142 a.a.) and having a molecular mass of 18.6kDa.LGALS10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). |
| NCBI Summary: | Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q05315 |
| NCBI GenInfo Identifier: | 317373429 |
| NCBI Gene ID: | 1178 |
| NCBI Accession: | Q05315.3 |
| UniProt Secondary Accession: | Q05315,Q0VDE3, C5HZ13, C5HZ14, |
| UniProt Related Accession: | Q05315 |
| Molecular Weight: | 16,453 Da |
| NCBI Full Name: | Galectin-10 |
| NCBI Synonym Full Names: | Charcot-Leyden crystal galectin |
| NCBI Official Symbol: | CLC |
| NCBI Official Synonym Symbols: | GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN |
| NCBI Protein Information: | galectin-10 |
| UniProt Protein Name: | Galectin-10 |
| UniProt Synonym Protein Names: | Charcot-Leyden crystal protein; CLC; Eosinophil lysophospholipase; Lysolecithin acylhydrolase |
| Protein Family: | Clathrin |
| UniProt Gene Name: | CLC |
| UniProt Entry Name: | LEG10_HUMAN |
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