Human Legumain/LGMN Recombinant Protein (RPES3243)

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SKU:
RPES3243
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human Legumain/LGMN Recombinant Protein

Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.

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