Human LECT1 (214-333) Recombinant Protein (RPPB5902)

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SKU:
RPPB5902
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
LECT1 (214-333)
Synonyms:
BRICD3
Synonyms:
CHM-I
Synonyms:
CHM1
Synonyms:
MYETS1
Source:
Escherichia Coli
Uniprot:
O75829
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Description

Product Name:Human LECT1 (214-333) Recombinant Protein
Product Code:RPPB5902
Size:20µg
Species:Human
Target:LECT1 (214-333)
Synonyms:BRICD3, CHM-I, CHM1, MYETS1, Leukocyte cell-derived chemotaxin 1, Chondrosurfactant protein, CH-SP, Chondromodulin-1, ChM-I, LECT1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The LECT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSREVVRKI VPTTTKRPHS GPRSNPGAGR LNNETRPSVQ EDSQAFNPDN PYHQEGESMT FDPRLDHEGI CCIECRRSYT HCQKICEPLG GYYPWPYNYQ GCRSACRVIM PCSWWVARIL GMV

Leukocyte Cell Derived Chemotaxin 1 (214-333 a.a.), also known as LECT1, is a glycosylated transmembrane protein which is cleaved to form a mature, secreted protein. The mature protein encourages chondrocyte growth and inhibits angiogenesis. The mature protein takes part in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. LECT1 is expressed in the avascular area of prehypertrophic cartilage and its expression reduces during vascular invasion and chondrocyte hypertrophy.

LECT1 Human Recombinant produced in E. coli is. a single polypeptide chain containing 143 amino acids (214-333) and having a molecular mass of 16.2kDa. LECT1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LECT1: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. Belongs to the chondromodulin-1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14.3

Biological Process: negative regulation of angiogenesis; proteoglycan metabolic process; skeletal development

NCBI Summary:This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:O75829
NCBI GenInfo Identifier:18202146
NCBI Gene ID:11061
NCBI Accession:O75829.1
UniProt Secondary Accession:O75829,Q5TAM4, Q8TAY6, Q9UM18,
UniProt Related Accession:O75829
Molecular Weight:36,974 Da
NCBI Full Name:Leukocyte cell-derived chemotaxin 1
NCBI Synonym Full Names:leukocyte cell derived chemotaxin 1
NCBI Official Symbol:LECT1  
NCBI Official Synonym Symbols:CHM1; CHM-I; BRICD3; MYETS1  
NCBI Protein Information:leukocyte cell-derived chemotaxin 1
UniProt Protein Name:Leukocyte cell-derived chemotaxin 1
UniProt Synonym Protein Names:Chondrosurfactant protein; CH-SP
Protein Family:Leukocyte cell-derived chemotaxin
UniProt Gene Name:LECT1  
UniProt Entry Name:LECT1_HUMAN
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