Human LDLR Recombinant Protein (RPES3717)

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SKU:
RPES3717
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human LDLR Recombinant Protein

Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.

Product Name:Human LDLR Recombinant Protein (RPES3717)
Product Code:RPES3717
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Low-Density Lipoprotein Receptor, LDL Receptor, LDLR,FH,FHC,LDL R,LDL Receptor,LDLCQ2
Accession:P01130
Sequence:Ala22-Arg788
Fusion tag:C-6His/AVI
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Low-Density Lipoprotein Receptor is produced by our Mammalian expression system and the target gene encoding Ala22-Arg788 is expressed with a AVI, 6His tag at the C-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:90.1 kDa
AP Mol Mass:137 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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