Human LAT Recombinant Protein (RPPB3845)

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SKU:
RPPB3845
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
LAT
Synonyms:
Linker for activation of T cells
Synonyms:
LAT1
Synonyms:
36 kDa phospho-tyrosine adapter protein
Synonyms:
p36-38
Source:
Escherichia Coli
Uniprot:
O43561
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Description

Product Name:Human LAT Recombinant Protein
Product Code:RPPB3845
Size:10µg
Species:Human
Target:LAT
Synonyms:Linker for activation of T cells, LAT1, 36 kDa phospho-tyrosine adapter protein, p36-38, pp36, linker for activation of T cells transmembrane adaptor, linker for activation of T-cells family member 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LAT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MHCHRLPGSY DSTSSDSLYP RGIQFKRPHT VAPWPPAYPP VTSYPPLSQP DLLPIPRSPQ PLGGSHRTPS SRRDSDGANS VASYENEEPA CEDADEDEDD YHNPGYLVVL PDSTPATSTA APSAPALSTP GIRDSAFSME SIDDYVNVPE SGESAEASLD GSREYVNVSQ ELHPGAAKTE PAALSSQEAE EVEEEGAPDY ENLQELN

LAT is a vital membrane protein that is phosphorylated by ZAP-70/Syk protein tyrosine kinases succeeding activation of the T-cell antigen receptor (TCR) signal transduction pathway. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes.

LAT Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (28-233) and having a molecular mass of 24.4 kDa (Molecular weight on SDS-PAGE will appear higher).LAT is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
NCBI Summary:The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:O43561
NCBI GenInfo Identifier:14194891
NCBI Gene ID:27040
NCBI Accession:O43561.1
UniProt Secondary Accession:O43561,O43919, B7WPI0, C7C5T6, G5E9K3,
UniProt Related Accession:O43561
Molecular Weight:27,774 Da
NCBI Full Name:Linker for activation of T-cells family member 1
NCBI Synonym Full Names:linker for activation of T-cells
NCBI Official Symbol:LAT  
NCBI Official Synonym Symbols:LAT1; pp36  
NCBI Protein Information:linker for activation of T-cells family member 1
UniProt Protein Name:Linker for activation of T-cells family member 1
UniProt Synonym Protein Names:36 kDa phospho-tyrosine adapter protein; pp36; p36-38
Protein Family:Latexin
UniProt Gene Name:LAT  
UniProt Entry Name:LAT_HUMAN
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