Human LAMP3 Recombinant Protein (RPPB3840)

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SKU:
RPPB3840
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
LAMP3
Synonyms:
Lysosomal-AssociatedMembrane Protein 3
Synonyms:
DC-Lysosome-Associated Membrane Glycoprotein
Synonyms:
DC LAMP
Synonyms:
LAMP-3
Source:
Sf9 Insect cells
Uniprot:
Q9UQV4
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Description

Product Name:Human LAMP3 Recombinant Protein
Product Code:RPPB3840
Size:10µg
Species:Human
Target:LAMP3
Synonyms:Lysosomal-AssociatedMembrane Protein 3, DC-Lysosome-Associated Membrane Glycoprotein, DC LAMP,LAMP-3, DCLAMP, TSC403, Protein TSC403, CD208 Antigen, DC-LAMP, CD208, LAMP, Lysosome-associatedmembrane glycoprotein 3.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LAMP3 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:KAFPETRDYS QPTAAATVQD IKKPVQQPAK QAPHQTLAAR FMDGHITFQTAATVKIPTTT PATTKNTATT SPITYTLVTT QATPNNSHTA PPVTEVTVGP SLAPYSLPPT ITPPAHTTGTSSSTVSHTTG NTTQPSNQTT LPATLSIALH KSTTGQKPVQ PTHAPGTTAA AHNTTRTAAPASTVPGPTLA PQPSSVKTGI YQVLNGSRLC IKAEMGIQLI VQDKESVFSPRRYFNIDPNA TQASGNCGTR KSNLLLNFQG GFVNLTFTKD EESYYISEVG AYLTVSDPET IYQGIKHAVVMFQTAVGHSF KCVSEQSLQL SAHLQVKTTD VQLQAFDFED DHFGNVDECS SDYTLEHHHHHH

Lysosomal-Associated Membrane Protein 3, also known as LAMP3 is part ofthe lysosome-associated membrane protein family. LAMP3 and CD68 share anextremely similar predicted structure. LAMP3 performs in dendritic cellfunction and in adaptive immunity as well. Furthermore, LAMP3 overexpression is actively involved in tumor invasion via increased migration into lymph-vascular spaces.

LAMP3 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 362 amino acids (28-381a.a.) andhaving a molecular mass of 38.8kDa. (Molecular size on SDS-PAGE will appear atapproximately 57-70kDa).LAMP3 is expressed with an8 amino acid His tag at C-Terminus and purified by proprietary chromatographictechniques.

UniProt Protein Function:LAMP3: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. Belongs to the LAMP family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.3-q27

Cellular Component: lysosomal membrane; integral to membrane

Biological Process: cell proliferation; immune system process

NCBI Summary:Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]
UniProt Code:Q9UQV4
NCBI GenInfo Identifier:38455385
NCBI Gene ID:27074
NCBI Accession:NP_055213.2
UniProt Secondary Accession:Q9UQV4,O94781, Q8NEC8, D3DNS4,
UniProt Related Accession:Q9UQV4
Molecular Weight:44,346 Da
NCBI Full Name:lysosome-associated membrane glycoprotein 3
NCBI Synonym Full Names:lysosomal-associated membrane protein 3
NCBI Official Symbol:LAMP3  
NCBI Official Synonym Symbols:LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP  
NCBI Protein Information:lysosome-associated membrane glycoprotein 3; DC-lysosome-associated membrane glycoprotein
UniProt Protein Name:Lysosome-associated membrane glycoprotein 3
UniProt Synonym Protein Names:DC-lysosome-associated membrane glycoprotein; DC LAMP; Protein TSC403
Protein Family:Lysosome-associated membrane glycoprotein
UniProt Gene Name:LAMP3  
UniProt Entry Name:LAMP3_HUMAN
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