Human L Selectin Recombinant Protein (RPPB3879)
- SKU:
- RPPB3879
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- L Selectin
- Synonyms:
- L-selectin
- Lymph node homing receptor
- Leukocyte adhesion molecule 1
- LAM-1
- Source:
- Escherichia Coli
- Uniprot:
- P14151
Description
| Product Name: | Human L Selectin Recombinant Protein |
| Product Code: | RPPB3879 |
| Size: | 10µg |
| Species: | Human |
| Target: | L Selectin |
| Synonyms: | L-selectin, Lymph node homing receptor, Leukocyte adhesion molecule 1, LAM-1, Leukocyte surface antigen Leu-8, TQ1, gp90-MEL, Leukocyte-endothelial cell adhesion molecule 1, LECAM1, CD62 antigen-like family member L, CD62L antigen, LAM1, LNHR, LSEL, CD62L, LYAM1, Leu-8, PLNHR, hLHRc, Lyam-1, L-Sel. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | L-Sel is supplied in 1x PBS and 50% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. Single band on Western Blot. |
L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin, which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells, which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
L-Selectin Human Recombinant is expressed in E. coli containing 294 amino acids 39-332 fused to an amino terminal hexahistidine tag, having a total molecular weight of 37.55kDa.
| UniProt Protein Function: | SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23-q25 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding Biological Process: regulation of immune response; blood coagulation; cell adhesion; leukocyte migration; response to ATP Disease: Iga Nephropathy, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P14151 |
| NCBI GenInfo Identifier: | 126178 |
| NCBI Gene ID: | 6402 |
| NCBI Accession: | P14151.2 |
| UniProt Secondary Accession: | P14151,P15023, Q9UJ43, B2R6Q8, |
| UniProt Related Accession: | P14151 |
| Molecular Weight: | 43,618 Da |
| NCBI Full Name: | L-selectin |
| NCBI Synonym Full Names: | selectin L |
| NCBI Official Symbol: | SELL |
| NCBI Official Synonym Symbols: | TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1 |
| NCBI Protein Information: | L-selectin; gp90-MEL; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1 |
| UniProt Protein Name: | L-selectin |
| UniProt Synonym Protein Names: | CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L |
| Protein Family: | L-selectin |
| UniProt Gene Name: | SELL |
| UniProt Entry Name: | LYAM1_HUMAN |
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