Human KLRB1 Recombinant Protein (RPPB3800)

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SKU:
RPPB3800
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
KLRB1
Synonyms:
Killer cell lectin-like receptor subfamily B member 1
Synonyms:
Natural killer cell surface protein P1A
Synonyms:
C-type lectin domain family 5 member B
Synonyms:
CD161 antigen
Source:
Escherichia Coli
Uniprot:
Q12918
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Description

Product Name:Human KLRB1 Recombinant Protein
Product Code:RPPB3800
Size:20µg
Species:Human
Target:KLRB1
Synonyms:Killer cell lectin-like receptor subfamily B member 1, Natural killer cell surface protein P1A, C-type lectin domain family 5 member B, CD161 antigen, HNKR-P1a, CLEC5B, NKR, NKR-P1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The KLRB1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMQKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS

KLRB1 has an inhibitory role on natural killer (NK) cells cytotoxicity which are lymphocytes who facilitate cytotoxicity and secrete cytokines subsequent to immune stimulation. Some genes of the C-type lectin superfamily, like the rodent NKRP1 family of glycoproteins, are expressed by NK cells and take part in NK cell function regulation. KLRB1 holds an extracellular domain with a few characteristic motifs of C-type lectins, a transmembrane domain, and a cytoplasmic domain. Due to its external C terminus KLRB1 is considered to be a type II membrane protein.

KLRB1 Human Recombinant produced in E. coli is a single polypeptide chain containing 183 amino acids (67-225) and having a molecular mass of 21.0 kDa.KLRB1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
NCBI Summary:Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
UniProt Code:Q12918
NCBI GenInfo Identifier:74722301
NCBI Gene ID:3820
NCBI Accession:Q12918.1
UniProt Secondary Accession:Q12918,Q24K24,
UniProt Related Accession:Q12918
Molecular Weight:25,415 Da
NCBI Full Name:Killer cell lectin-like receptor subfamily B member 1
NCBI Synonym Full Names:killer cell lectin like receptor B1
NCBI Official Symbol:KLRB1  
NCBI Official Synonym Symbols:NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A  
NCBI Protein Information:killer cell lectin-like receptor subfamily B member 1
UniProt Protein Name:Killer cell lectin-like receptor subfamily B member 1
UniProt Synonym Protein Names:C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD_antigen: CD161
Protein Family:Killer cell lectin-like receptor subfamily
UniProt Gene Name:KLRB1  
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