Human KLK7 Recombinant Protein (RPPB1867)

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SKU:
RPPB1867
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
KLK7
Synonyms:
kallikrein-related peptidase 7
Synonyms:
SCCE
Synonyms:
hSCCE
Synonyms:
EC 3421117
Source:
Escherichia Coli
Uniprot:
P49862
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Description

Product Name:Human KLK7 Recombinant Protein
Product Code:RPPB1867
Size:20µg
Species:Human
Target:KLK7
Synonyms:kallikrein-related peptidase 7, SCCE, hSCCE, EC 3.4.21.117, hK7, Kallikrein-7, PRSS6, KLK7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:KLK7 protein 1mg/ml is supplied in 20mM Tris-HCl, pH-8, 2M Urea and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by Analysis by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMIIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIK ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL ENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDPGV YTQVCKFTKW INDTMKKHR

KLK7 catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. KLK7 is involved in the activation of precursors to inflammatory cytokines.

KLK7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 249 amino acids (30-253) and having a molecular mass of 27.1 kDa.The KLK7 is fused to a 25 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK7: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.21.35; Protease; Secreted

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region; extracellular space

Molecular Function:metalloendopeptidase activity; peptidase activity; serine-type peptidase activity

Biological Process: epidermis development; extracellular matrix disassembly; positive regulation of antibacterial peptide production

NCBI Summary:This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
UniProt Code:P49862
NCBI GenInfo Identifier:1710878
NCBI Gene ID:5650
NCBI Accession:P49862.1
UniProt Secondary Accession:P49862,Q8N5N9, Q8NFV7, A8K0U5,
UniProt Related Accession:P49862
Molecular Weight:19,887 Da
NCBI Full Name:Kallikrein-7
NCBI Synonym Full Names:kallikrein related peptidase 7
NCBI Official Symbol:KLK7  
NCBI Official Synonym Symbols:hK7; SCCE; PRSS6  
NCBI Protein Information:kallikrein-7
UniProt Protein Name:Kallikrein-7
UniProt Synonym Protein Names:Serine protease 6; Stratum corneum chymotryptic enzyme; hSCCE
Protein Family:Kallikrein
UniProt Gene Name:KLK7  
UniProt Entry Name:KLK7_HUMAN
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