Human KLK2 Recombinant Protein (RPPB1861)
- SKU:
- RPPB1861
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- KLK2
- Synonyms:
- hK2
- KLK2A2
- Kallikrein-2
- Glandular kallikrein-1
- Source:
- Sf9 Insect cells
- Uniprot:
- P20151
Description
Product Name: | Human KLK2 Recombinant Protein |
Product Code: | RPPB1861 |
Size: | 5µg |
Species: | Human |
Target: | KLK2 |
Synonyms: | hK2, KLK2A2, Kallikrein-2, Glandular kallikrein-1, hGK-1, issue kallikrein-2, KLK2. |
Source: | Sf9 Insect cells |
Physical Appearance: | Sterile Filtered colorless solution. |
Formulation: | KLK2 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
Purity: | Greater than 90.0% as determined by SDS-PAGE. |
Amino Acid Sequence: | ADPIVGGWEC EKHSQPWQVA VYSHGWAHCG GVLVHPQWVL TAAHCLKKNS QVWLGRHNLF EPEDTGQRVP VSHSFPHPLY NMSLLKHQSL RPDEDSSHDL MLLRLSEPAK ITDVVKVLGL PTQEPALGTT CYASGWGSIE PEEFLRPRSL QCVSLHLLSN DMCARAYSEK VTEFMLCAGL WTGGKDTCGG DSGGPLVCNG VLQGITSWGP EPCALPEKPA VYTKVVHYRK WIKDTIAANP HHHHHH |
KLK2 is a part of the grandular kallikrein protein family whose Members are engaged in a diverse array of biological functions. Kallikreins are a subgroup of serine proteases which are clustered on chromosome 19. KLK2 is a highly active trypsin-like serine protease which selectively cleaves at arginine remains. KLK2 is mostly expressed in prostatic tissue and is accountable for cleaving pro-prostate-specific antigen into its enzymatically active form. KLK2 is greatly expressed in prostate tumor cells and may possibly be a prognostic maker for prostate cancer risk.
KLK2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 246 amino acids (25-261 aa) and having a molecular mass of 27.2kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).KLK2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
UniProt Protein Function: | KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.21.35; Protease Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis |
NCBI Summary: | This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] |
UniProt Code: | P20151 |
NCBI GenInfo Identifier: | 125174 |
NCBI Gene ID: | 3817 |
NCBI Accession: | P20151.1 |
UniProt Secondary Accession: | P20151,Q15946, Q9UJZ9, B4DU93, B4DUB0, F5H8L3, |
UniProt Related Accession: | P20151 |
Molecular Weight: | 261 |
NCBI Full Name: | Kallikrein-2 |
NCBI Synonym Full Names: | kallikrein-related peptidase 2 |
NCBI Official Symbol: | KLK2 |
NCBI Official Synonym Symbols: | hK2; hGK-1; KLK2A2 |
NCBI Protein Information: | kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic |
UniProt Protein Name: | Kallikrein-2 |
UniProt Synonym Protein Names: | Glandular kallikrein-1; hGK-1; Tissue kallikrein-2 |
Protein Family: | Kallikrein |
UniProt Gene Name: | KLK2 |
UniProt Entry Name: | KLK2_HUMAN |