Human KLK13 Recombinant Protein (RPPB1874)
- SKU:
- RPPB1874
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- KLK13
- Synonyms:
- Kallikrein-13
- KLK-L4
- KLKL4
- Kallikrein-like protein 4
- Source:
- Escherichia Coli
- Uniprot:
- Q9UKR3
Description
| Product Name: | Human KLK13 Recombinant Protein |
| Product Code: | RPPB1874 |
| Size: | 5µg |
| Species: | Human |
| Target: | KLK13 |
| Synonyms: | Kallikrein-13, KLK-L4, KLKL4, Kallikrein-like protein 4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KLK13 protein solution (0.25mg/ml) containing 20mMTris-HCl (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSGGVSQES SKVLNTNGTS GFLPGGYTCF PHSQPWQAAL LVQGRLLCGGVLVHPKWVLT AAHCLKEGLK VYLGKHALGR VEAGEQVREV VHSIPHPEYR RSPTHLNHDH DIMLLELQSPVQLTGYIQTL PLSHNNRLTP GTTCRVSGWG TTTSPQVNYP KTLQCANIQL RSDEECRQVY PGKITDNMLCAGTKEGGKDS CEGDSGGPLV CNRTLYGIVS WGDFPCGQPD RPGVYTRVSR YVLWIRETIR KYETQQQKWLKGPQ |
Kallikreins are a subgroup of serine proteases having various physiological functions. Many kallikreins are implicated in carcinogenesis and some have potential of becoming novel cancer and other disease biomarkers. Kallikrein-13 (KLK13) is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK13 gene expression is regulated by steroid hormones and may be useful as a marker for breast cancer.
KLK13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 284 amino acids (17-277 a.a) and having a molecular mass of 31.3kDa.KLK13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Vesicle; Secreted; Secreted, signal peptide; Protease; EC 3.4.21.- Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space; cytoplasm; extracellular region; secretory granule Molecular Function:protein binding; hydrolase activity; serine-type endopeptidase activity Biological Process: protein processing; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKR3 |
| NCBI GenInfo Identifier: | 11496281 |
| NCBI Gene ID: | 26085 |
| NCBI Accession: | NP_056411.1 |
| UniProt Secondary Accession: | Q9UKR3,Q86VI8, Q9Y433, A7UNK6, |
| UniProt Related Accession: | Q9UKR3 |
| Molecular Weight: | 13,986 Da |
| NCBI Full Name: | kallikrein-13 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 13 |
| NCBI Official Symbol: | KLK13 |
| NCBI Official Synonym Symbols: | KLKL4; KLK-L4 |
| NCBI Protein Information: | kallikrein-13; kallikrein 13; kallikrein-like gene 4; kallikrein-like protein 4 |
| UniProt Protein Name: | Kallikrein-13 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 4; KLK-L4 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK13 |
| UniProt Entry Name: | KLK13_HUMAN |
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