Human KLK10 Recombinant Protein (RPPB1871)
- SKU:
- RPPB1871
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- KLK10
- Synonyms:
- Kallikrein-Related Peptidase 10
- KLK10
- PRSSL1
- NES1
- Source:
- Sf9 Insect cells
- Uniprot:
- O43240
Description
| Product Name: | Human KLK10 Recombinant Protein |
| Product Code: | RPPB1871 |
| Size: | 10µg |
| Species: | Human |
| Target: | KLK10 |
| Synonyms: | Kallikrein-Related Peptidase 10, KLK10, PRSSL1, NES1, Normal Epithelial Cell-Specific 1, Protease Serine-Like 1, Kallikrein 10, Breast Normal Epithelial Cell Associated Serine Protease, kallikrein-10, Protease, Serine-Like 1, EC 3.4.21.- , EC 3.4.21, EC 3.4.21.74. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KLK10 protein solution (0.5mg/ml) contains 30% glycerol, 20mM Tris-HCl (pH 8.0), 0.15M NaCl & 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPALLPQND TRLDPEAYGS PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSNHHHH HH |
Kallikrein-10 (KLK10) is one of the 15 kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are a subgroup of serine proteases having various physiological functions. KLK10 is secreted and has a role in suppression of tumorigenesis in breast and prostate cancers.
KLK10 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (34-276 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 252 amino acids and having a molecular mass of 27.8kDa.KLK10 shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLK10: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Tumor suppressor; Protease; Secreted, signal peptide; EC 3.4.21.- Chromosomal Location of Human Ortholog: 19q13 Molecular Function:serine-type peptidase activity |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43240 |
| NCBI GenInfo Identifier: | 317373432 |
| NCBI Gene ID: | 5655 |
| NCBI Accession: | O43240.3 |
| UniProt Secondary Accession: | O43240,Q53YL3, Q99920, Q9GZW9, A6NC12, |
| UniProt Related Accession: | O43240 |
| Molecular Weight: | 30,170 Da |
| NCBI Full Name: | Kallikrein-10 |
| NCBI Synonym Full Names: | kallikrein related peptidase 10 |
| NCBI Official Symbol: | KLK10 |
| NCBI Official Synonym Symbols: | NES1; PRSSL1 |
| NCBI Protein Information: | kallikrein-10 |
| UniProt Protein Name: | Kallikrein-10 |
| UniProt Synonym Protein Names: | Normal epithelial cell-specific 1; Protease serine-like 1 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK10 |
| UniProt Entry Name: | KLK10_HUMAN |
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