Human KIR2DL1 Recombinant Protein (RPPB3785)
- SKU:
- RPPB3785
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- KIR2DL1
- Synonyms:
- Killer cell immunoglobulin-like receptor 2DL1
- MHC class I NK cell receptor
- Natural killer-associated transcript 1
- NKAT-1
- Source:
- Escherichia Coli
- Uniprot:
- P43626
Description
| Product Name: | Human KIR2DL1 Recombinant Protein |
| Product Code: | RPPB3785 |
| Size: | 20µg |
| Species: | Human |
| Target: | KIR2DL1 |
| Synonyms: | Killer cell immunoglobulin-like receptor 2DL1, MHC class I NK cell receptor, Natural killer-associated transcript 1, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, p58 NK receptor, p58.1 MHC class-I-specific NK receptor, CD158 antigen-like family member A, CD158a antigen, KIR2DL1, CD158A, NKAT1, NKAT, p58.1, KIR221, KIR-K64. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein (1mg/ml) contains 25mM Tris- HCl (pH-7.5). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN |
Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface glycoproteins found on Natural Killer (NK) Cells, which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). KIR molecules are extremely polymorphic, meaning their gene sequences differ significantly between individuals, so that different individuals have different arrays/repertoires of KIR genes.The KIR proteins are categorized by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM). Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DL1 is an inhibitory Killer Cell Ig-like Receptor (KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules (HLA-Cw2, -Cw4, -Cw5, and Cw6). The extracellular domain of KIR2DL1 was over expressed as insoluble protein aggregates (inclusion bodies).
KIR2DL1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2 kDa.The KIR2DL1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KIR2DL1: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Belongs to the immunoglobulin superfamily. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; receptor activity Biological Process: regulation of immune response; natural killer cell inhibitory signaling pathway; immune response |
| NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43626 |
| NCBI GenInfo Identifier: | 1171726 |
| NCBI Gene ID: | 3802 |
| NCBI Accession: | P43626.1 |
| UniProt Secondary Accession: | P43626,O43470, Q32WE6, Q6IST4, |
| UniProt Related Accession: | P43626 |
| Molecular Weight: | 348 |
| NCBI Full Name: | Killer cell immunoglobulin-like receptor 2DL1 |
| NCBI Synonym Full Names: | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 |
| NCBI Official Symbol: | KIR2DL1 |
| NCBI Official Synonym Symbols: | NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64 |
| NCBI Protein Information: | killer cell immunoglobulin-like receptor 2DL1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibit |
| UniProt Protein Name: | Killer cell immunoglobulin-like receptor 2DL1 |
| UniProt Synonym Protein Names: | CD158 antigen-like family member A; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD_antigen: CD158a |
| UniProt Gene Name: | KIR2DL1 |
| UniProt Entry Name: | KI2L1_HUMAN |
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