Human Ketohexokinase Recombinant Protein (RPPB2558)
- SKU:
- RPPB2558
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- Ketohexokinase
- Synonyms:
- KHK
- Hepatic Fructokinase
- Ketohexokinase
- Fructokinase
- Source:
- Escherichia Coli
- Uniprot:
- P50053
Description
| Product Name: | Human Ketohexokinase Recombinant Protein |
| Product Code: | RPPB2558 |
| Size: | 25µg |
| Species: | Human |
| Target: | Ketohexokinase |
| Synonyms: | KHK, Hepatic Fructokinase, Ketohexokinase, Fructokinase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein solution contains 1xPBS, pH 7.4 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV |
Ketohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. ketohexokinase plays an unknown physiologic function that remains intact in essential fructosuria. Ketohexokinase expression is reduceed in human clear cell type of renal cell carcinoma.
Ketohexokinase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa.
| UniProt Protein Function: | Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. |
| NCBI Summary: | This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50053 |
| NCBI GenInfo Identifier: | 816380035 |
| NCBI Gene ID: | 3795 |
| NCBI Accession: | P50053.2 |
| UniProt Secondary Accession: | P50053,Q6IBK2, Q99532, Q9BRJ3, Q9UMN1, |
| UniProt Related Accession: | P50053 |
| Molecular Weight: | 32,730 Da |
| NCBI Full Name: | Ketohexokinase |
| NCBI Synonym Full Names: | ketohexokinase |
| NCBI Official Symbol: | KHK |
| NCBI Protein Information: | ketohexokinase |
| UniProt Protein Name: | Ketohexokinase |
| UniProt Synonym Protein Names: | Hepatic fructokinase |
| Protein Family: | Ketohexokinase |
| UniProt Gene Name: | KHK |
| UniProt Entry Name: | KHK_HUMAN |
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