Human ITGA5 Recombinant Protein (RPES1682)
- SKU:
- RPES1682
- Product type:
- Recombinant Protein
- Host species:
- Human Cells
- Reactivity:
- Human
Frequently bought together:
Description
system_update_alt데이터시트
Human ITGA5 Recombinant Protein
Integrin ?-5 belongs to the Integrin ? chain family and contains 7 FG-GAP repeats. Integrin ?-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts; endothelial cells; peripheral T cells and platelets. Integrin ?-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion; ITGA5 participates in cell-surface mediated signalling.
| Product Name: | Human ITGA5 Recombinant Protein (RPES1682) |
| Product Code: | RPES1682 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Integrin Alpha-5, CD49 Antigen-Like Family Member E, Fibronectin Receptor Subunit Alpha, Integrin Alpha-F, VLA-5, CD49e, ITGA5, FNRA |
| Accession: | P08648 |
| Sequence: | Phe42-Tyr995 |
| Fusion tag: | C-6His |
| Activity: | Immobilized Human NovoNectin(Cat: PKSH032450) at 2µg/ml(100 ?l/well) can bind Human ITGA5-His. The ED50 of Human ITGA5-His is 18.9 ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Integrin ?-5 is produced by our Mammalian expression system and the target gene encoding Phe42-Tyr995 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 105.1 kDa |
| AP Mol Mass: | 130 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.2. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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