Human IPP-POZ Recombinant Protein (RPPB5897)
- SKU:
- RPPB5897
- Product type:
- Recombinant Protein
- Size:
- 50ug
- Species:
- Human
- Target:
- IPP-POZ
- Synonyms:
- Intracisternal A Particle-Promoted Polypeptide
- Actin-binding protein IPP
- MIPP protein
- Kelch-like protein 27
- Source:
- Escherichia Coli
- Uniprot:
- Q9Y573
Description
| Product Name: | Human IPP-POZ Recombinant Protein |
| Product Code: | RPPB5897 |
| Size: | 50µg |
| Species: | Human |
| Target: | IPP-POZ |
| Synonyms: | Intracisternal A Particle-Promoted Polypeptide, Actin-binding protein IPP, MIPP protein, Kelch-like protein 27, IPP, KLHL27, IPP-POZ. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein (1mg/ml) containing 10mM HEPES (pH7.4) and 25mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSPYFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLTEVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF |
Intracisternal A particle-promoted polypeptide (IPP) is a 66kDa protein (584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminal kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT.
IPP-POZ Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids & having a molecular mass of 17.3 kDa.
| UniProt Protein Function: | IPP: May play a role in organizing the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 1p34-p32Cellular Component: cytoplasm; actin cytoskeletonMolecular Function: actin binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y573 |
| NCBI GenInfo Identifier: | 5174473 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_005888.1 |
| UniProt Secondary Accession: | Q9Y573 |
| UniProt Related Accession: | Q9Y573 |
| Molecular Weight: | |
| NCBI Full Name: | actin-binding protein IPP isoform 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Actin-binding protein IPP |
| UniProt Synonym Protein Names: | Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27 |
| Protein Family: | Actin-binding protein |
| UniProt Gene Name: | IPP |
| UniProt Entry Name: | IPP_HUMAN |
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