Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains; which presumably mediate binding of an as yet unidentified ligand; a transmembrane region; and an intracellular domain; which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1); a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent; especially the memory and concentration capability.
Product Name:
Human ILR8/IL1RAPL1 Recombinant Protein (RPES0874)
Product Code:
RPES0874
Size:
10µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
IL1R8,IL1RAPL,MRX10,MRX21,MRX34,OPHN4,TIGIRR-2
Accession:
NP_055086.1
Sequence:
Met 1-Leu 354
Fusion tag:
C-Fc
Activity:
Measured by its ability to bind biotinylated human IL1? in functional ELISA.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human IL1R8 (NP_055086.1) extracellular domain (Met 1-Leu 354) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
65 kDa
AP Mol Mass:
80-85 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
