Human IL36RN Recombinant Protein (RPPB0675)

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주문
SKU:
RPPB0675
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
IL36RN
Synonyms:
Interleukin 36 receptor antagonist
Synonyms:
FIL1
Synonyms:
FIL1(DELTA)
Synonyms:
FIL1D
Source:
Escherichia Coli
Uniprot:
Q9UBH0
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Description

Product Name:Human IL36RN Recombinant Protein
Product Code:RPPB0675
Size:20µg
Species:Human
Target:IL36RN
Synonyms:Interleukin 36 receptor antagonist, FIL1, FIL1(DELTA),FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, FIL1 delta, Interleukin-1HY1, IL-1 delta, Interleukin-1 receptor antagonist homolog 1,Interleukin-1-like protein 1, UNQ1896/PRO4342.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL36RN protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSHMVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG VQGGSQCLSCGVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF LCTVPEADQP VRLTQLPENGGWNAPITDFY FQQCD

Human interleukin family 1, member 5 (IL-1F5 / FIL1-delta) belongs to the interleukin 1 cytokine family. IL1F5 is expressed by a variety of cells including monocytes, Bcells, dendritic cells/Langerhans cells, keratinocytes,and gastric fundus Parietal and Chief cells. IL1F5 is an antagonist of IL1F9; however IL1F5 activity related to receptor binding remains unclear. Human and mouse IL1F5 share 90% amino acid sequence identity.

IL36RN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids (1-155 a.a) and having a molecular mass of 19.1kDa.IL36RN is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1F5: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response. Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP). PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. Belongs to the IL-1 family.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 2q14

Cellular Component: extracellular space

Molecular Function:cytokine activity; interleukin-1 receptor binding; protein binding

Biological Process: antifungal humoral response; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of interleukin-17 production

Disease: Psoriasis 14, Pustular

NCBI Summary:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBH0
NCBI GenInfo Identifier:25008600
NCBI Gene ID:26525
NCBI Accession:Q9UBH0.1
UniProt Secondary Accession:Q9UBH0,Q56AT9, Q7RTZ6, A8K2I4,
UniProt Related Accession:Q9UBH0
Molecular Weight:16,962 Da
NCBI Full Name:Interleukin-36 receptor antagonist protein
NCBI Synonym Full Names:interleukin 36 receptor antagonist
NCBI Official Symbol:IL36RN  
NCBI Official Synonym Symbols:FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)  
NCBI Protein Information:interleukin-36 receptor antagonist protein
UniProt Protein Name:Interleukin-36 receptor antagonist protein
UniProt Synonym Protein Names:FIL1 delta; IL-1-related protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; Interleukin-1-like protein 1; IL-1L1
Protein Family:Interleukin-36 receptor antagonist protein
UniProt Gene Name:IL36RN  
UniProt Entry Name:I36RA_HUMAN
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