Human IL36RN Recombinant Protein (RPPB0673)
- SKU:
- RPPB0673
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- IL36RN
- Synonyms:
- Interleukin-36 receptor antagonist protein
- FIL1 delta
- IL-1-related protein 3
- IL-1RP3
- Source:
- Escherichia Coli
- Uniprot:
- Q9UBH0
Description
| Product Name: | Human IL36RN Recombinant Protein |
| Product Code: | RPPB0673 |
| Size: | 25µg |
| Species: | Human |
| Target: | IL36RN |
| Synonyms: | Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1, Interleukin-1 delta, IL-1 delta, Interleukin-1 family member 5, IL-1F5, Interleukin-1 receptor antagonist homolog 1, IL-1ra homolog 1, Interleukin-1-like protein 1, IL-1L1, IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, FIL1, PSORP, IL36RA, FIL1(DELTA). |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IL1F5 was lyophilized after extensive dialysis against 20mM Phosphate buffer, pH7.4. |
| Solubility: | It is recommended to quick spin followed by reconstitution of IL1F5 in PBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL1F5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL1F5 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Val-Leu-Ser-Gly |
| Biological Activity: | As measured by its binding ability in a functional ELISA, immobilized IL1F5 at 1 µg/ml (100 µl/well) can bind rHuIL-1 Rrp2/Fc Chimera with a linear range of 0.15- 5 µg/ml. |
Human interleukin family 1, member 5 (IL-1F5 / FIL1-delta) belongs to the interleukin 1 cytokine family. IL1F5 is expressed by a variety of cells including monocytes, Bcells, dendritic cells/Langerhans cells, keratinocytes,and gastric fundus Parietal and Chief cells. IL1F5 is an antagonist of IL1F9; however IL1F5 activity related to receptor binding remains unclear. Human and mouse IL1F5 share 90% amino acid sequence identity.
IL1F5 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 155 amino acids and having a molecular mass of 17kDa.The IL1F5 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL1F5: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response. Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP). PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. Belongs to the IL-1 family. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 2q14 Cellular Component: extracellular space Molecular Function:cytokine activity; interleukin-1 receptor binding; protein binding Biological Process: antifungal humoral response; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of interleukin-17 production Disease: Psoriasis 14, Pustular |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBH0 |
| NCBI GenInfo Identifier: | 25008600 |
| NCBI Gene ID: | 26525 |
| NCBI Accession: | Q9UBH0.1 |
| UniProt Secondary Accession: | Q9UBH0,Q56AT9, Q7RTZ6, A8K2I4, |
| UniProt Related Accession: | Q9UBH0 |
| Molecular Weight: | 16,962 Da |
| NCBI Full Name: | Interleukin-36 receptor antagonist protein |
| NCBI Synonym Full Names: | interleukin 36 receptor antagonist |
| NCBI Official Symbol: | IL36RN |
| NCBI Official Synonym Symbols: | FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA) |
| NCBI Protein Information: | interleukin-36 receptor antagonist protein |
| UniProt Protein Name: | Interleukin-36 receptor antagonist protein |
| UniProt Synonym Protein Names: | FIL1 delta; IL-1-related protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; Interleukin-1-like protein 1; IL-1L1 |
| Protein Family: | Interleukin-36 receptor antagonist protein |
| UniProt Gene Name: | IL36RN |
| UniProt Entry Name: | I36RA_HUMAN |
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