Human IL21 Recombinant Protein (RPPB0633)
- SKU:
- RPPB0633
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- IL21
- Synonyms:
- Interleukin-21 isoform 1
- CVID11
- IL-21
- Za11
- Source:
- Sf9 Insect cells
- Uniprot:
- Q9HBE4
Description
| Product Name: | Human IL21 Recombinant Protein |
| Product Code: | RPPB0633 |
| Size: | 5µg |
| Species: | Human |
| Target: | IL21 |
| Synonyms: | Interleukin-21 isoform 1, CVID11, IL-21, Za11. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL21 protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPEFMQGQD RHMIRMRQLI DIVDQLKNYV NDLVPEFLPA PEDVETNCEW SAFSCFQKAQ LKSANTGNNE RIINVSIKKL KRKPPSTNAGRRQKHRLTCP SCDSYEKKPP KEFLERFKSL LQKMIHQHLS SRTHGSEDSH HHHHH |
Interleukin-21 isoform 1 or IL21, categorized as a T helper cytokine. IL21 is part of the regulation of immune responses, haematopoiesis and cell-mediated responses. IL21 has a key role in haematopoiesis and immune responses regulation, therefore can affect lymphocyte development. Activation of T cells leads to production of the IL21. The protein has a crucial role in the viral infections persistence.
IL21 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 145 amino acids (30-162a.a.) and having a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).IL21 is expressed with a 12 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 4q26-q27 Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding Biological Process: cell maturation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat3 protein Disease: Immunodeficiency, Common Variable, 11 |
| NCBI Summary: | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HBE4 |
| NCBI GenInfo Identifier: | 55976599 |
| NCBI Gene ID: | 59067 |
| NCBI Accession: | Q9HBE4.2 |
| UniProt Secondary Accession: | Q9HBE4,A5J0L4, |
| UniProt Related Accession: | Q9HBE4 |
| Molecular Weight: | 16,867 Da |
| NCBI Full Name: | Interleukin-21 |
| NCBI Synonym Full Names: | interleukin 21 |
| NCBI Official Symbol: | IL21 |
| NCBI Official Synonym Symbols: | Za11; IL-21; CVID11 |
| NCBI Protein Information: | interleukin-21 |
| UniProt Protein Name: | Interleukin-21 |
| UniProt Synonym Protein Names: | Za11 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL21 |
| UniProt Entry Name: | IL21_HUMAN |
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