Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein andbelongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepaticstellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokinethat has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 inproduced in several T helper populations, it is proposed that it provides a feedback loop to limit theeffector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viablebiomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. Inaddition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviralinfections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possibleclinical use of IL-10 in suppressing rejections of grafts after organ transplantations.
Product Name:
Human IL0/Interleukin0 Recombinant Protein (RPES1347)
Recombinant Human Interleukin-10 is produced by our Mammalian expression system and the target gene encoding Ser19-Asn178 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
19.6 kDa
AP Mol Mass:
16 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
