PE Anti-Human IL-21 Antibody [3A3-N2] (AGEL2051)

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SKU:
AGEL2051
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE Anti-Human IL-21 Antibody [3A3-N2]

The Human IL-21 Monoclonal Antibody PE-Conjugated (3A3-N2) is a vital tool for researchers investigating the functions of interleukin-21 (IL-21) in immune responses and diseases. This antibody, conjugated with phycoerythrin (PE) for fluorescence-based applications, specifically targets IL-21, a cytokine with diverse roles in the immune system.IL-21 is known for its involvement in regulating immune responses, particularly in promoting B and T cell differentiation and function. Its dysregulation has been linked to various immune-related disorders, including autoimmune diseases and inflammatory conditions.

The PE-conjugated monoclonal antibody 3A3-N2 recognizes IL-21 with high specificity, allowing for precise detection and analysis of this key cytokine in experimental settings.By utilizing this antibody, researchers can explore the intricate mechanisms by which IL-21 impacts immune cell activities and disease processes. From investigating the therapeutic potential of IL-21 modulation to uncovering its role in immune-mediated pathologies, this antibody provides a valuable tool for advancing our understanding of immune regulation and potential treatment strategies.

Product Title:PE Anti-Human IL-21 Antibody [3A3-N2]
SKU:AGEL2051
Size:20 Tests, 100 Tests, 200 Tests
Clone No:3A3-N2
Synonyms:Interleukin-21;IL-21;Za11;
Host Species:Mouse
Reactivity:Human
Application:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9HBE4
Gene ID:59067
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

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