Human IL 17B Recombinant Protein (RPPB0599)
- SKU:
- RPPB0599
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- IL 17B
- Synonyms:
- Interleukin-17B
- IL-17B
- Cytokine Zcyto7
- Interleukin-20
- Source:
- Escherichia Coli
- Uniprot:
- Q9UHF5
Description
| Product Name: | Human IL 17B Recombinant Protein |
| Product Code: | RPPB0599 |
| Size: | 25µg |
| Species: | Human |
| Target: | IL 17B |
| Synonyms: | Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor, IL20, NIRF, ZCYTO7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Interleukin-17B was Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH7.4, 0.05% Tween-20 and 3%Trehalose. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 17B in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin 17B although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL17B should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F |
| Biological Activity: | The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0µg/ml, corresponding to a specific activity of > 1000 IU/mg. |
IL-17 family members are glycoproteins secreted as dimers which induce local cytokine production and recruit granulocytes to sites of inflammation. The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 is induced by IL-15 and IL-23, mostly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL17B Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway.
Interleukin-17B Human Recombinant produced in E.Coli is a homodimeric, non-disulfide-linked polypeptide chain containing a total of 322 amino acids (2 chains of 161aa) and having a molecular mass of 36.5kDa. The IL-17B is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. |
| NCBI Summary: | The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9UHF5 |
| NCBI GenInfo Identifier: | 20143877 |
| NCBI Gene ID: | 27190 |
| NCBI Accession: | Q9UHF5.1 |
| UniProt Secondary Accession: | Q9UHF5,Q14CE5, |
| UniProt Related Accession: | Q9UHF5 |
| Molecular Weight: | 20,437 Da |
| NCBI Full Name: | Interleukin-17B |
| NCBI Synonym Full Names: | interleukin 17B |
| NCBI Official Symbol: | IL17B |
| NCBI Official Synonym Symbols: | NIRF; IL-20; IL-17B; ZCYTO7 |
| NCBI Protein Information: | interleukin-17B |
| UniProt Protein Name: | Interleukin-17B |
| UniProt Synonym Protein Names: | Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal interleukin-17-related factor |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17B |
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