PE Anti-Human IL-17A Antibody [BL168] (AGEL1857)

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SKU:
AGEL1857
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE Anti-Human IL-17A Antibody [BL168]

The Human IL-17A Monoclonal Antibody (PE Conjugated) BL168 (AGEL1857) is a cutting-edge tool designed for researchers delving into the intricate world of immune responses. The antibody, meticulously crafted for specificity and sensitivity, targets the IL-17A protein, a crucial cytokine involved in inflammation and autoimmune diseases.IL-17A, a key player in the immune system's defense against pathogens, also contributes to chronic inflammatory conditions when dysregulated. This monoclonal antibody, expertly engineered for precise binding to human IL-17A, allows for accurate detection and quantification in various experimental setups.

Its PE conjugation enhances signal amplification, enabling robust flow cytometry analysis and fluorescence microscopy imaging.In the realm of immunology and disease research, the IL-17A Monoclonal Antibody serves as a beacon of exploration, shedding light on the roles of IL-17A in conditions such as rheumatoid arthritis, multiple sclerosis, and psoriasis. By unraveling the mechanisms underlying IL-17A signaling, researchers can pave the way for innovative therapeutic interventions aimed at modulating immune responses for improved patient outcomes.

Product Title:PE Anti-Human IL-17A Antibody [BL168]
SKU:AGEL1857
Size:20 Tests, 100 Tests, 200 Tests
Clone No:BL168
Synonyms:CTLA8; IL17;CTLA-8;IL 17A;
Host Species:Mouse
Reactivity:Human
Application:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q16552
Gene ID:3605
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.

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