Human IL 17 Recombinant Protein (RPPB0596)
- SKU:
- RPPB0596
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- IL 17
- Synonyms:
- CTLA-8
- IL-17
- IL-17A
- Cytotoxic T-lymphocyte-associated antigen 8
- Source:
- Escherichia Coli
- Uniprot:
- Q16552
Description
Product Name: | Human IL 17 Recombinant Protein |
Product Code: | RPPB0596 |
Size: | 25µg |
Species: | Human |
Target: | IL 17 |
Synonyms: | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8. |
Source: | Escherichia Coli |
Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation: | Sterile filtered lyophilized (freeze-dried) powder, with 20mM Citrate, 0.1M NaCl, pH4.5. |
Solubility: | It is recommended to reconstitute the lyophilized Interleukin 17 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Stability: | Lyophilized Interleukin 17A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Purity: | Greater than 95.0% as determined by SDS-PAGE. |
Biological Activity: | The ED50 as determined by the dose-dependent induction of IL-6 in Hs68 cell line was found to be approximately 2ng/ml corresponding to a Specific Activity of 500,000IU/mg. |
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa. The IL-17 is purified by proprietary chromatographic techniques.
UniProt Protein Function: | IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p12 Cellular Component: extracellular space; external side of plasma membrane Molecular Function:cytokine activity Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response |
NCBI Summary: | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16552 |
NCBI GenInfo Identifier: | 2498481 |
NCBI Gene ID: | 3605 |
NCBI Accession: | Q16552.1 |
UniProt Secondary Accession: | Q16552,Q5T2P0, |
UniProt Related Accession: | Q16552 |
Molecular Weight: | 17,504 Da |
NCBI Full Name: | Interleukin-17A |
NCBI Synonym Full Names: | interleukin 17A |
NCBI Official Symbol: | IL17A |
NCBI Official Synonym Symbols: | IL17; CTLA8; IL-17; IL-17A |
NCBI Protein Information: | interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
UniProt Protein Name: | Interleukin-17A |
UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
Protein Family: | Interleukin |
UniProt Gene Name: | IL17A |
UniProt Entry Name: | IL17_HUMAN |