Human IGSF8 Recombinant Protein (RPPB3741)

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SKU:
RPPB3741
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
IGSF8
Synonyms:
Immunoglobulin Superfamily Member 8
Synonyms:
Keratinocytes-Associated Transmembrane Protein 4
Synonyms:
Glu-Trp-Ile EWI Motif-Containing Protein 2
Synonyms:
Prostaglandin Regulatory-Like Protein
Source:
Sf9 Insect cells
Uniprot:
Q969P0
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Description

Product Name:Human IGSF8 Recombinant Protein
Product Code:RPPB3741
Size:5µg
Species:Human
Target:IGSF8
Synonyms:Immunoglobulin Superfamily Member 8, Keratinocytes-Associated Transmembrane Protein 4, Glu-Trp-Ile EWI Motif-Containing Protein 2, Prostaglandin Regulatory-Like Protein, CD81 Partner 3, CD81P3, LIR-D1, EWI-2, KCT-4, EWI2, PGRL, Immunoglobulin Superfamily Member 8, CD316 Antigen, CD316, IgSF8, KCT4. 
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IGSF8 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADLREVLVPE GPLYRVAGTA VSISCNVTGY EGPAQQNFEW FLYRPEAPDT ALGIVSTKDT QFSYAVFKSR VVAGEVQVQR LQGDAVVLKI ARLQAQDAGI YECHTPSTDT RYLGSYSGKV ELRVLPDVLQ VSAAPPGPRG RQAPTSPPRM TVHEGQELAL GCLARTSTQK HTHLAVSFGR SVPEAPVGRS TLQEVVGIRS DLAVEAGAPY AERLAAGELR LGKEGTDRYR MVVGGAQAGD AGTYHCTAAE WIQDPDGSWA QIAEKRAVLA HVDVQTLSSQ LAVTVGPGER RIGPGEPLEL LCNVSGALPP AGRHAAYSVG WEMAPAGAPG PGRLVAQLDT EGVGSLGPGY EGRHIAMEKV ASRTYRLRLE AARPGDAGTY RCLAKAYVRG SGTRLREAAS ARSRPLPVHV REEGVVLEAV AWLAGGTVYR GETASLLCNI SVRGGPPGLR LAASWWVERP EDGELSSVPA QLVGGVGQDG VAELGVRPGG GPVSVELVGP RSHRLRLHSL GPEDEGVYHC APSAWVQHAD YSWYQAGSAR SGPVTVYPYM HALDTHHHHH H

Immunoglobulin superfamily member 8 (IGSF8) belongs to the immunoglobulin protein superfamily. IGSF8 interacts with the tetraspanins CD81 and CD9 and may regulate their role in a number of cellular functions including cell migration and viral infection. In addition, the IGSF8 protein may function as a tumor suppressor by inhibiting the proliferation of certain cancers.

IGSF8 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 561 amino acids (28-579a.a.) and having a molecular mass of 59.6kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). IGSF8 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IGSF8: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: integral to membrane; membrane

Molecular Function:protein binding

NCBI Summary:This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
UniProt Code:Q969P0
NCBI GenInfo Identifier:74762642
NCBI Gene ID:93185
NCBI Accession:Q969P0.1
UniProt Secondary Accession:Q969P0,Q8NG09, Q96DP4, Q9BTG9,
UniProt Related Accession:Q969P0
Molecular Weight:55,808 Da
NCBI Full Name:Immunoglobulin superfamily member 8
NCBI Synonym Full Names:immunoglobulin superfamily member 8
NCBI Official Symbol:IGSF8  
NCBI Official Synonym Symbols:EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1  
NCBI Protein Information:immunoglobulin superfamily member 8
UniProt Protein Name:Immunoglobulin superfamily member 8
UniProt Synonym Protein Names:CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; EWI-2; Keratinocytes-associated transmembrane protein 4; KCT-4; LIR-D1; Prostaglandin regulatory-like protein; PGRL; CD_antigen: CD316
Protein Family:Immunoglobulin superfamily
UniProt Gene Name:IGSF8  
UniProt Entry Name:IGSF8_HUMAN
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