Human IGJ Recombinant Protein (RPPB3740)
- SKU:
- RPPB3740
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- IGJ
- Synonyms:
- IGCJ
- JCH
- Immunoglobulin J chain
- IGJ
- Source:
- Escherichia Coli
- Uniprot:
- P01591
Description
| Product Name: | Human IGJ Recombinant Protein |
| Product Code: | RPPB3740 |
| Size: | 20µg |
| Species: | Human |
| Target: | IGJ |
| Synonyms: | IGCJ, JCH, Immunoglobulin J chain, IGJ. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IGJ solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQEDERIV LVDNKCKCAR ITSRIIRSSE DPNEDIVERN IRIIVPLNNR ENISDPTSPL RTRFVYHLSD LCKKCDPTEV ELDNQIVTAT QSNICDEDSA TETCYTYDRN KCYTAVVPLV YGGETKMVET ALTPDACYPD |
Immunoglobulin J chain (IGJ) helps to link 2 monomer units of either IgM or IgA and also also helps to bind these immunoglobulins to secretory component. When it comes to IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer and in the case of IgA it induces larger polymers.
IGJ Human Recombinant produced in E. coli is a single polypeptide chain containing 160 amino acids (23-159) and having a molecular mass of 18kDa. IGJ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IGJ: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular region; extracellular space Molecular Function:IgA binding; peptidoglycan binding; phosphatidylcholine binding; protein homodimerization activity; single-stranded DNA binding Biological Process: adaptive immune response; antibacterial humoral response; glomerular filtration; innate immune response; positive regulation of protein oligomerization; receptor-mediated endocytosis; retinal homeostasis |
| UniProt Code: | P01591 |
| NCBI GenInfo Identifier: | 261260100 |
| NCBI Gene ID: | 3512 |
| NCBI Accession: | P01591.4 |
| UniProt Related Accession: | P01591 |
| Molecular Weight: | 18,099 Da |
| NCBI Full Name: | Immunoglobulin J chain |
| NCBI Synonym Full Names: | joining chain of multimeric IgA and IgM |
| NCBI Official Symbol: | JCHAIN |
| NCBI Official Synonym Symbols: | IGJ; JCH; IGCJ |
| NCBI Protein Information: | immunoglobulin J chain |
| UniProt Protein Name: | Immunoglobulin J chain |
| UniProt Synonym Protein Names: | Joining chain of multimeric IgA and IgM |
| UniProt Gene Name: | JCHAIN |
| UniProt Entry Name: | IGJ_HUMAN |
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