Human IGFBP 5 Recombinant Protein (RPPB0435)

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SKU:
RPPB0435
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
IGFBP 5
Synonyms:
IGFBP-5
Synonyms:
IBP-5
Synonyms:
IGF-binding protein 5
Source:
Escherichia Coli
Uniprot:
P24593
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Description

Product Name:Human IGFBP 5 Recombinant Protein
Product Code:RPPB0435
Size:25µg
Species:Human
Target:IGFBP 5
Synonyms:IGFBP-5, IBP-5, IGF-binding protein 5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10mM sodium Citrate pH-3.
Solubility:It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-5 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IBP5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP 5 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE
Biological Activity:The ED50, calculated by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is < 0.4µg/ml, corresponding to a specific activity of > 2500 IU/mg in the presence of 15ng/ml of rHuIGF-II.

IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

IGFBP5 Human Recombinant produced in E.Coli is non-glycosylated homodimer containing 2x252 amino acids and having a molecular mass of 28.6kDa. IGFBP5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProt Code:P24593
NCBI GenInfo Identifier:124069
NCBI Gene ID:3488
NCBI Accession:P24593.1
UniProt Secondary Accession:P24593,Q5U0A3,
UniProt Related Accession:P24593
Molecular Weight:
NCBI Full Name:Insulin-like growth factor-binding protein 5
NCBI Synonym Full Names:insulin like growth factor binding protein 5
NCBI Official Symbol:IGFBP5  
NCBI Official Synonym Symbols:IBP5  
NCBI Protein Information:insulin-like growth factor-binding protein 5
UniProt Protein Name:Insulin-like growth factor-binding protein 5
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP5  
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