Human IGF/IGF1 Recombinant Protein (RPES1582)
- SKU:
- RPES1582
- Product type:
- Recombinant Protein
- Host species:
- E.coli
- Reactivity:
- Human
Frequently bought together:
Description
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Human IGF/IGF1 Recombinant Protein
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R; IGF-2R; and the insulin receptor and plays a key role in cell cycle progression; cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
| Product Name: | Human IGF/IGF1 Recombinant Protein (RPES1582) |
| Product Code: | RPES1582 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Insulin-Like Growth Factor I, IGF-I, Mechano Growth Factor, MGF, Somatomedin-C, IGF1, IBP1 |
| Accession: | P05019 |
| Sequence: | Thr52-Ala118 |
| Fusion tag: | |
| Activity: | Measured in a serum-free cell proliferation assay using MCF?7 human breast cancer cells. The ED50 for this effect is 52.4 ng/ml. |
| Endotoxin: | <0.5 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Insulin-like Growth Factor I is produced by our E.coli expression system and the target gene encoding Thr52-Ala118 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 7.3 kDa |
| AP Mol Mass: | 9 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 300mM NaAc; pH 6.5. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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