Human IFNW1 Recombinant Protein (RPPB0409)

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SKU:
RPPB0409
Product type:
Recombinant Protein
Size:
100ug
Species:
Human
Target:
IFNW1
Synonyms:
IFN omega-1
Synonyms:
IFN alpha-II-1
Synonyms:
IFNW1
Source:
Escherichia Coli
Uniprot:
P05000
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Description

Product Name:Human IFNW1 Recombinant Protein
Product Code:RPPB0409
Size:100µg
Species:Human
Target:IFNW1
Synonyms:IFN omega-1, IFN alpha-II-1, IFNW1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized IFNW1 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IFNW1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFNW1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MCDLPQNHGL LSRNTLVLLH QMRRISPFLC LKDRRDFRFP QEMVKGSQLQ KAHVMSVLHE MLQQIFSLFH TERSSAAWNM TLLDQLHTGL HQQLQHLETC LLQVVGEGES AGAISSPALT LRRYFQGIRV YLKEKKYSDC AWEVVRMEIM KSLFLSTNMQ ERLRSKDRDL GSS
Biological Activity:The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 100,000,000 units/mg.

IFN-Omega 1 is a type I IFN, that can be induced by virus-infected leukocytes. Type I IFN family members, which include IFN-alpha, IFN-beta, and IFN-omega, signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities. IFNW1 exhibits about 75% sequence homology with IFN-a, and contains 2 conserved disulfide bonds, which are essential for full biological activity.

IFN-Omega 1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.9kDa.The IFN-Omega 1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IFNW1: Belongs to the alpha/beta interferon family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; cell cycle arrest; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein

UniProt Code:P05000
NCBI GenInfo Identifier:400061
NCBI Gene ID:3467
NCBI Accession:P05000.2
UniProt Secondary Accession:P05000,Q13168, Q5U802, Q5VWD0, Q7M4P5,
UniProt Related Accession:P05000
Molecular Weight:22,319 Da
NCBI Full Name:Interferon omega-1
NCBI Synonym Full Names:interferon, omega 1
NCBI Official Symbol:IFNW1  
NCBI Protein Information:interferon omega-1; interferon alpha-II-1; IFN-omega 1, interferon omega-1
UniProt Protein Name:Interferon omega-1
UniProt Synonym Protein Names:Interferon alpha-II-1
UniProt Gene Name:IFNW1  
UniProt Entry Name:IFNW1_HUMAN
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