The Interferon-?/β Receptor 1 (IFN-?/β R1) is a receptor which binds Type I Interferons including Interferon-? and -β. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-?/β R1, in association with IFN-?/β R2, is required for propagating antiviral signal transduction triggered by IFN-? and IFN-β. IFN-?/β R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-?/β R2. Ligands associate with IFN-?/β R2, and this complex subsequently forms a stable ternary assembly with IFN-?/β R1. IFN-?/β R1 also associates with IFN-? R2 even in the absence of IFN-? stimulation. Human IFN-?/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
Product Name:
Human IFNAR1/IFNAR Recombinant Protein (RPES1762)
Product Code:
RPES1762
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Interferon Alpha/Beta Receptor 1, IFN-R-1, IFN-Alpha/Beta Receptor 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I Interferon Receptor 1,IFNAR1,IFNAR,AVP,IFN-alpha-REC
Accession:
P17181
Sequence:
Lys28-Lys436
Fusion tag:
C-6His
Activity:
Immobilized Human IFN alpha2b(Cat: PKSH033640) at 2µg/ml(100 ?l/well) can bind Human IFNAR1-His.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Interferon alpha/beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Lys28-Lys436 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
48.2 kDa
AP Mol Mass:
78 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
