Human IFNA1A Recombinant Protein (RPPB0380)
- SKU:
- RPPB0380
- Product type:
- Recombinant Protein
- Size:
- 100ug
- Species:
- Human
- Target:
- IFNA1A
- Synonyms:
- IFN-alpha 1a
- IFN-a 1a
- IFN alpha 1a
- Source:
- Escherichia Coli
- Uniprot:
- P01562
Description
| Product Name: | Human IFNA1A Recombinant Protein |
| Product Code: | RPPB0380 |
| Size: | 100µg |
| Species: | Human |
| Target: | IFNA1A |
| Synonyms: | IFN-alpha 1a, IFN-a 1a, IFN alpha 1a. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The IFN-a 1a protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, containing 3% Mannitol, 5% Trehalose, 0.05% Tween-80. |
| Solubility: | It is recommended to reconstitute the lyophilized IFN alpha 1a in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IFNA1A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-alpha 1a should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MCDLPETHSL DNRRTLMLLA QMSRISPSSC LMDRHDFGFP QEEFDGNQFQ KAPAISVLHE LIQQIFNLFT TKDSSAAWDE DLLDKFCTEL YQQLNDLEAC VMQEERVGET PLMNADSILA VKKYFRRITL YLTEKKYSPC AWEVVRAEIM RSLSLSTNLQ ERLRRKE |
| Biological Activity: | The specific activity as determined in a viral resistance assay viral ressistance assay was found to be 100,000,000IU/ mg. |
At least 23 different variants of IFN-alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.
IFN-alpha 1a Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids and having a molecular mass of 19.5kDa. The IFNA1A ( V115A ) is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IFNA1/13: a cytokine that belongs to the alpha/beta interferon family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 9p22 Cellular Component: extracellular space; extracellular region Molecular Function:interferon-alpha/beta receptor binding; cytokine activity Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein |
| NCBI Summary: | The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P01562 |
| NCBI GenInfo Identifier: | 124455 |
| NCBI Gene ID: | 3439 |
| NCBI Accession: | P01562.1 |
| UniProt Secondary Accession: | P01562,Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68 Q9UMJ3, D4Q9M8, |
| UniProt Related Accession: | P01562 |
| Molecular Weight: | 21,725 Da |
| NCBI Full Name: | Interferon alpha-1/13 |
| NCBI Synonym Full Names: | interferon, alpha 1 |
| NCBI Official Symbol: | IFNA1 |
| NCBI Official Synonym Symbols: | IFL; IFN; IFNA@; IFNA13; IFN-ALPHA; IFN-alphaD |
| NCBI Protein Information: | interferon alpha-1/13; leIF D; IFN-alpha 1b; IFN-alpha-1/13; interferon-alpha1; interferon alpha-D; interferon alpha 1b |
| UniProt Protein Name: | Interferon alpha-1/13 |
| UniProt Synonym Protein Names: | Interferon alpha-D |
| Protein Family: | Mitochondrial brown fat uncoupling protein |
| UniProt Gene Name: | IFNA1 |
| UniProt Entry Name: | IFNA1_HUMAN |
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