Human IFN g Recombinant Protein (RPPB0397)
- SKU:
- RPPB0397
- Product type:
- Recombinant Protein
- Size:
- 50ug
- Species:
- Human
- Target:
- IFN g
- Synonyms:
- Immune Interferon
- type II interferon
- T cell interferon
- MAF
- Source:
- Escherichia Coli
- Uniprot:
- P01579
Description
Product Name: | Human IFN g Recombinant Protein |
Product Code: | RPPB0397 |
Size: | 50µg |
Species: | Human |
Target: | IFN g |
Synonyms: | Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI, IFN-gamma. |
Source: | Escherichia Coli |
Physical Appearance: | Sterile Filtered clear solution. |
Formulation: | Interferon-g is supplied in phosphate-buffered Saline (pH 7.4). |
Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Purity: | Greater than 90.0% as determined by analysis by SDS-PAGE. |
Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRG |
IFN-gamma produced by lymphocytes activated by specific antigens or mitogens.IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
IFN-Gamma Human Recombinant produced in E.Coli is a single, glycosylated polypeptide chain containing 159 amino acids (24-161 a.a) without cysteine residues and having a molecular mass of 18.5kDa (confirmed by MALDI-TOF). Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.IFN-Gamma is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
UniProt Protein Function: | IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 12q14 Cellular Component: extracellular space; extracellular region; external side of plasma membrane Molecular Function:interferon-gamma receptor binding; cytokine activity Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; apoptosis; positive regulation of interleukin-23 production; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-12 production; positive regulation of osteoclast differentiation; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; positive regulation of interleukin-1 beta secretion; positive regulation of killing of cells of another organism; negative regulation of transcription from RNA polymerase II promoter; sensory perception of mechanical stimulus; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; adaptive immune response; CD8-positive, alpha-beta T cell differentiation during immune response; negative regulation of myelination; unfolded protein response; response to virus; cytokine and chemokine mediated signaling pathway; defense response to protozoan; positive regulation of tumor necrosis factor production; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of chemokine biosynthetic process; negative regulation of interleukin-17 production; positive regulation of interleukin-12 biosynthetic process; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; cell motility; positive regulation of neuron differentiation; regulation of insulin secretion Disease: Hepatitis C Virus, Susceptibility To; Aplastic Anemia; Tuberous Sclerosis 2; Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To |
NCBI Summary: | This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] |
UniProt Code: | P01579 |
NCBI GenInfo Identifier: | 124479 |
NCBI Gene ID: | 3458 |
NCBI Accession: | P01579.1 |
UniProt Secondary Accession: | P01579,Q53ZV4, B5BU88, |
UniProt Related Accession: | P01579 |
Molecular Weight: | |
NCBI Full Name: | Interferon gamma |
NCBI Synonym Full Names: | interferon, gamma |
NCBI Official Symbol: | IFNG |
NCBI Official Synonym Symbols: | IFG; IFI |
NCBI Protein Information: | interferon gamma; IFN-gamma; immune interferon |
UniProt Protein Name: | Interferon gamma |
UniProt Synonym Protein Names: | Immune interferon |
Protein Family: | Interferon |
UniProt Gene Name: | IFNG |
UniProt Entry Name: | IFNG_HUMAN |