Human IFN b 1b Recombinant Protein (RPPB0394)

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SKU:
RPPB0394
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
IFN b 1b
Synonyms:
Leukocyte IFN
Synonyms:
B cell IFN
Synonyms:
Type I IFN
Synonyms:
IFNB1
Source:
Escherichia Coli
Uniprot:
P01574
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Description

Product Name:Human IFN b 1b Recombinant Protein
Product Code:RPPB0394
Size:10µg
Species:Human
Target:IFN b 1b
Synonyms:Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1b, MGC96956.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from 1mg/ml solution containing 50mg Human Albumin & 50mg dextrose.
Solubility:It is recommended to reconstitute the lyophilized IFN beta-1b in sterile 18M-cm H2O at a concentration of 0.25mg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IFN-beta 1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFNB 1b should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Tyr-Asn-Leu-Leu
Biological Activity:The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 106 IU/mg.

IFN-beta 1b has antiviral, antibacterial and anticancer activities.

IFN beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IFN beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. IFN beta-1b is purified by proprietary chromatographic techniques.

UniProt Protein Function:IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function:interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein

UniProt Code:P01574
NCBI GenInfo Identifier:124469
NCBI Gene ID:3456
NCBI Accession:P01574.1
UniProt Secondary Accession:P01574,Q5VWC9,
UniProt Related Accession:P01574
Molecular Weight:187
NCBI Full Name:Interferon beta
NCBI Synonym Full Names:interferon, beta 1, fibroblast
NCBI Official Symbol:IFNB1  
NCBI Official Synonym Symbols:IFB; IFF; IFNB  
NCBI Protein Information:interferon beta; IFN-beta; fibroblast interferon
UniProt Protein Name:Interferon beta
UniProt Synonym Protein Names:Fibroblast interferon
Protein Family:Interferon
UniProt Gene Name:IFNB1  
UniProt Entry Name:IFNB_HUMAN
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