Human IFN a 2a Recombinant Protein (RPPB0383)

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SKU:
RPPB0383
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
IFN a 2a
Synonyms:
Leukocyte interferon
Synonyms:
B cell interferon
Synonyms:
Type I interferon
Synonyms:
IFNA2
Source:
Nicotiana SpPlant
Uniprot:
P01563
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Description

Product Name:Human IFN a 2a Recombinant Protein
Product Code:RPPB0383
Size:25µg
Species:Human
Target:IFN a 2a
Synonyms:Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN-a 2a.
Source:Nicotiana SpPlant
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized, containing 50% SDS.
Solubility:It is recommended to reconstitute the lyophilized Interferon-alpha 2a in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interferon alpha 2a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-alpha 2a should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 99.0% as determined by both:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first twelve N-terminal amino acids was determined and was found to be Cys-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Ser-Arg
Biological Activity:The specific activity was determined by a quantitative gene report bioassay using human Type I interferon-sensitive cells. Compared with bacterial derived recombinant IFN-a 2a, assayed in the same conditions, plant derived IFN-alpha 2a showed 6.1 × 108 Units/mg in reference to a viral resistance assay using bovine kidney MDBK cells.

IFN-alpha is produced by macrophages and has antiviral activities. Interferon stimulates the production of two enzymes: protein kinase and an oligoadenylate synthetase.

Interferon Alpha Human 2a Recombinant produced in Plant is a single, glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19 kDa.The Interferon-a 2a contains affinity 6xHis tag on C-terminus.The IFN-A 2a is purified by proprietary chromatographic techniques.

UniProt Protein Function:Produced by macrophages, IFN-alpha have antiviral activities.
NCBI Summary:This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
UniProt Code:P01563
NCBI GenInfo Identifier:124449
NCBI Gene ID:3440
NCBI Accession:P01563.1
UniProt Secondary Accession:P01563,P01564, Q14606, Q6DJX8, Q96KI6, H2DF54, H2DF55
UniProt Related Accession:P01563
Molecular Weight:21,550 Da
NCBI Full Name:Interferon alpha-2
NCBI Synonym Full Names:interferon alpha 2
NCBI Official Symbol:IFNA2  
NCBI Official Synonym Symbols:IFNA; INFA2; IFNA2B; IFN-alphaA  
NCBI Protein Information:interferon alpha-2
UniProt Protein Name:Interferon alpha-2
UniProt Synonym Protein Names:Interferon alpha-A; LeIF A
UniProt Gene Name:IFNA2  
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