Human IFIT3 Recombinant Protein (RPPB0378)

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SKU:
RPPB0378
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
IFIT3
Synonyms:
IFN-Induced Protein With Tetratricopeptide Repeats 3
Synonyms:
IFN-Induced Protein With Tetratricopeptide Repeats 4
Synonyms:
IFIT4
Synonyms:
Retinoic Acid-Induced Gene G Protein
Source:
Escherichia Coli
Uniprot:
O14879
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Description

Product Name:Human IFIT3 Recombinant Protein
Product Code:RPPB0378
Size:20µg
Species:Human
Target:IFIT3
Synonyms:IFN-Induced Protein With Tetratricopeptide Repeats 3, IFN-Induced Protein With Tetratricopeptide Repeats 4, IFIT4, Retinoic Acid-Induced Gene G Protein, IFN-Induced 60 KDa Protein, IFI-60K, CIG-49, IFIT-3, IFIT-4, ISG-60, CIG49, IFI60, ISG60, RIG-G, P60, GARG-49, IRG2, IFN-induced protein with tetratricopeptide repeats 3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IFIT3 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSEVTKN SLEKILPQLK CHFTWNLFKE DSVSRDLEDR VCNQIEFLNTEFKATMYNLL AYIKHLDGNN EAALECLRQA EELIQQEHAD QAEIRSLVTW GNYAWVYYHL GRLSDAQIYVDKVKQTCKKF SNPYSIEYSE LDCEEGWTQL KCGRNERAKV CFEKALEEKP NNPEFSSGLA IAMYHLDNHPEKQFSTDVLK QAIELSPDNQ YVKVLLGLKL QKMNKEAEGE QFVEEALEKS PCQTDVLRSA AKFYRRKGDLDKAIELFQRV LESTPNNGYL YHQIGCCYKA KVRQMQNTGE SEASGNKEMI EALKQYAMDY SNKALEKGLNPLNAYSDLAE FLETECYQTP FNKEVPDAEK QQSHQRYCNL QKYNGKSEDT AVQHGLEGLS ISKKSTDKEEIKDQPQNVSE NLLPQNAPNY WYLQGLIHKQ NGDLLQAAKC YEKELGRLLR DAPSGIGSIF LSASELEDGSEEMGQGAVSS SPRELLSNSE QLN

IFN-Induced Protein With Tetratricopeptide Repeats 3, also known as IFIT3 is a member of the IFIT family. IFN-induced antiviral protein which performs as an inhibitor of cellular and viral processes, cell migration, proliferation, signaling, as well as viral replication. Furthermore, IFIT3 is significantly induced upon RNA virus infection. Ectopic expression or alternatively knockdown of IFIT3 might, respectively, enhance or impair IRF3-mediated gene expression.

IFIT3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 513 amino acids (1-490 a.a) andhaving a molecular mass of 58.4kDa.IFIT3 is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.

UniProt Protein Function:IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function:identical protein binding; protein binding

Biological Process: negative regulation of cell proliferation; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of apoptosis

UniProt Code:O14879
NCBI GenInfo Identifier:6831570
NCBI Gene ID:3437
NCBI Accession:O14879.1
UniProt Secondary Accession:O14879,Q99634, Q9BSK7,
UniProt Related Accession:O14879
Molecular Weight:490
NCBI Full Name:Interferon-induced protein with tetratricopeptide repeats 3
NCBI Synonym Full Names:interferon-induced protein with tetratricopeptide repeats 3
NCBI Official Symbol:IFIT3  
NCBI Official Synonym Symbols:P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; CIG-49; GARG-49  
NCBI Protein Information:interferon-induced protein with tetratricopeptide repeats 3; CIG49; IFIT-3; IFIT-4; ISG-60; IFI-60K; interferon-induced 60 kDa protein; retinoic acid-induced gene G protein; interferon-induced protein with tetratricopeptide repeats 4
UniProt Protein Name:Interferon-induced protein with tetratricopeptide repeats 3
UniProt Synonym Protein Names:CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G
Protein Family:Interferon-induced protein with tetratricopeptide repeats
UniProt Gene Name:IFIT3  
UniProt Entry Name:IFIT3_HUMAN
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