Human HTF Recombinant Protein (RPPB2895)
- SKU:
- RPPB2895
- Product type:
- Recombinant Protein
- Size:
- 1gram
- Species:
- Human
- Target:
- HTF
- Synonyms:
- Serotransferrin
- Transferrin
- Siderophilin
- Beta-1-metal-binding globulin
- Source:
- Human serum
- Uniprot:
- P02787
Description
| Product Name: | Human HTF Recombinant Protein |
| Product Code: | RPPB2895 |
| Size: | 1gram |
| Species: | Human |
| Target: | HTF |
| Synonyms: | Serotransferrin, Transferrin, Siderophilin, Beta-1-metal-binding globulin, TF, PRO1557, PRO2086, DKFZp781D0156, Holo Transferrin, HTF. |
| Source: | Human serum |
| Physical Appearance: | Sterile Filtered Pink lyophilized (freeze-dried) powder. |
| Formulation: | The protein (10mg/ml) was lyophilized from 20mM NH4HC03 solution. May contain traces of buffer salts. |
| Solubility: | It is recommended to reconstitute the lyophilized Holo Transferrin in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Store the lyophilized Holo Transferrin between 2-8°C, do not freeze. Upon reconstitution Apo Transferrin should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by coomassie blue stained SDS-PAGE and Cellulose Acetate electrophoresis. |
Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture. It is referred to frequently as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.Human Transferrin is a crucial component for the cultivation of mammalian cells in-vitro. Human Transferrin is Critical for long-term cells growth in-vitro. Human Transferrin is used as detoxificant in media by binding contaminating metal ions. Human Transferrin is often used as a nutrient in fermentation media for recombinant protein and biopharmaceutical production. Additional common uses of Human Transferrin areMolecular weight, Affinity purification of anti-human transferrin antibodies and also as receptor mediated transfection of molecules such as DNA, into cells.
Human Holo Transferrin is a glycoprotein of approximately 77 kDa.
| UniProt Protein Function: | TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: extracellular space; cell surface; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle Molecular Function:protein binding; ferric iron binding; ubiquitin protein ligase binding Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport Disease: Atransferrinemia |
| NCBI Summary: | This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P02787 |
| NCBI GenInfo Identifier: | 313104271 |
| NCBI Gene ID: | 7018 |
| NCBI Accession: | P02787.3 |
| UniProt Secondary Accession: | P02787,O43890, Q1HBA5, Q9NQB8, Q9UHV0, |
| UniProt Related Accession: | P02787 |
| Molecular Weight: | 77,064 Da |
| NCBI Full Name: | Serotransferrin |
| NCBI Synonym Full Names: | transferrin |
| NCBI Official Symbol: | TF |
| NCBI Official Synonym Symbols: | TFQTL1; PRO1557; PRO2086 |
| NCBI Protein Information: | serotransferrin; siderophilin; beta-1 metal-binding globulin |
| UniProt Protein Name: | Serotransferrin |
| UniProt Synonym Protein Names: | Beta-1 metal-binding globulin; Siderophilin |
| Protein Family: | Transferrin |
| UniProt Gene Name: | TF |
| UniProt Entry Name: | TRFE_HUMAN |
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