Human HSPB2 Recombinant Protein (RPPB5252)

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SKU:
RPPB5252
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
HSPB2
Synonyms:
Heat shock 27kDa protein 2
Synonyms:
DMPK-binding protein
Synonyms:
MKBP
Synonyms:
HSP27
Source:
Escherichia Coli
Uniprot:
Q16082
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Description

Product Name:Human HSPB2 Recombinant Protein
Product Code:RPPB5252
Size:20µg
Species:Human
Target:HSPB2
Synonyms:Heat shock 27kDa protein 2, DMPK-binding protein, MKBP, HSP27, LOH11CR1K.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HSPB2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSGRSV PHAHPATAEY EFANPSRLGE QRFGEGLLPE EILTPTLYHG YYVRPRAAPA GEGSRAGASE LRLSEGKFQA FLDVSHFTPD EVTVRTVDNL LEVSARHPQR LDRHGFVSRE FCRTYVLPAD VDPWRVRAAL SHDGILNLEA PRGGRHLDTE VNEVYISLLP APPDPEEEEE AAIVEP

Heat shock protein beta-2 (HSPB2) is a member of the small heat shock protein (HSP20) family. HSPB2 is a regulator of DMPK kinase.

HSPB2 Human Recombinant produced in E. coli is a single polypeptide chain containing 206 amino acids (1-182) and having a molecular mass of 22.8kDa.HSPB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HSPB2: May regulate the kinase DMPK. Belongs to the small heat shock protein (HSP20) family.
UniProt Protein Details:

Protein type:Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:enzyme activator activity; protein binding

Biological Process: positive regulation of catalytic activity; response to heat; response to unfolded protein; somatic muscle development

NCBI Summary:The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
UniProt Code:Q16082
NCBI GenInfo Identifier:6016268
NCBI Gene ID:3316
NCBI Accession:Q16082.2
UniProt Secondary Accession:Q16082,Q6I9U7,
UniProt Related Accession:Q16082
Molecular Weight:20,233 Da
NCBI Full Name:Heat shock protein beta-2
NCBI Synonym Full Names:heat shock protein family B (small) member 2
NCBI Official Symbol:HSPB2  
NCBI Official Synonym Symbols:MKBP; HSP27; Hs.78846; LOH11CR1K  
NCBI Protein Information:heat shock protein beta-2
UniProt Protein Name:Heat shock protein beta-2
UniProt Synonym Protein Names:DMPK-binding protein; MKBP
Protein Family:Heat shock protein
UniProt Gene Name:HSPB2  
UniProt Entry Name:HSPB2_HUMAN
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