Human HSP27/HSPB1 Recombinant Protein (RPES3947)

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SKU:
RPES3947
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human HSP27/HSPB1 Recombinant Protein

HSP27 is a member of the small heat shock protein family, which also includes HSP25 and the alpha -crystallins. HSP27 forms a large oligomer and the extent of phosphorylation plays a role in determining specific functions. HSP27 also functions as an anti-apoptotic molecule, regulating apoptosis through direct interaction with key components of the apoptotic pathway. HSP27 binds and sequesters cytochrome c released from the mitochondria in response to an apoptotic stimulus. This prevents the proper assembly of the apoptosome and subsequently, the activation of procaspase-9 and procaspase-3.

Product Name:Human HSP27/HSPB1 Recombinant Protein (RPES3947)
Product Code:RPES3947
Size:50µg
Species:Human
Expressed Host:E.coli
Synonyms:CMT2F,HEL-S-102,HMN2B,HS.76067,Hsp25,HSP27,HSP28,SRP27
Accession:NP_001531.1
Sequence:Met 1-Lys205
Fusion tag:C-His
Endotoxin:Please contact us for more information.
Protein Construction:A DNA sequence encoding the human HSP27 (NP_001531.1) (Met1-Lys205) was expressed with a C-terminal polyhistidine tag.
Purity:> 97 % as determined by reducing SDS-PAGE.
Mol Mass:28 kDa
AP Mol Mass:28 kDa
Formulation:Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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