Human HOXB13 Recombinant Protein (RPPB3714)

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SKU:
RPPB3714
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
HOXB13
Synonyms:
Homeobox B13
Synonyms:
Homeobox Protein Hox-B13
Synonyms:
PSGD
Source:
Escherichia Coli
Uniprot:
Q92826
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Description

Product Name:Human HOXB13 Recombinant Protein
Product Code:RPPB3714
Size:20µg
Species:Human
Target:HOXB13
Synonyms:Homeobox B13, Homeobox Protein Hox-B13, PSGD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:HOXB13 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEPGNYA TLDGAKDIEG LLGAGGGRNL VAHSPLTSHP AAPTLMPAVN YAPLDLPGSA EPPKQCHPCP GVPQGTSPAP VPYGYFGGGY YSCRVSRSSL KPCAQAATLA AYPAETPTAG EEYPSRPTEF AFYPGYPGTY QPMASYLDVS VVQTLGAPGE PRHDSLLPVD SYQSWALAGG WNSQMCCQGE QNPPGPFWKA AFADSSGQHP PDACAFRRGR KKRIPYSKGQ LRELEREYAA NKFITKDKRR KISAATSLSE RQITIWFQNR RVKEKKVLAK VKNSATP

HOXB13 is a transcription factor and a member of the homeobox gene family which are extremely conserved in vertebrates and vital for vertebrate embryonic development. HOXB13 is involved in fetal skin development and cutaneous regeneration. In mice, a similar gene displayed temporal and spatial colinearity in the main body axis of the embryo, however it was not expressed in the secondary axes, implying that it has a roles in body patterning along the axis.

HOXB13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284 a.a) and having a molecular mass of 33.1kDa.HOXB13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HOXB13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nucleoplasm

Biological Process: angiogenesis; epidermis development; response to wounding

NCBI Summary:This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
UniProt Code:Q92826
NCBI GenInfo Identifier:50403792
NCBI Gene ID:10481
NCBI Accession:Q92826.2
UniProt Secondary Accession:Q92826,Q96QM4, Q99810, B2R878,
UniProt Related Accession:Q92826
Molecular Weight:30,676 Da
NCBI Full Name:Homeobox protein Hox-B13
NCBI Synonym Full Names:homeobox B13
NCBI Official Symbol:HOXB13  
NCBI Official Synonym Symbols:PSGD  
NCBI Protein Information:homeobox protein Hox-B13
UniProt Protein Name:Homeobox protein Hox-B13
Protein Family:Homeobox protein
UniProt Gene Name:HOXB13  
UniProt Entry Name:HXB13_HUMAN
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