Human HMGB3 Recombinant Protein (RPPB3700)

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SKU:
RPPB3700
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
HMGB3
Synonyms:
High Mobility Group Box 3
Synonyms:
High-Mobility Group (Nonhistone Chromosomal) Protein 4
Synonyms:
Non-Histone Chromosomal Protein
Synonyms:
High Mobility Group Protein B3
Source:
Escherichia Coli
Uniprot:
O15347
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Description

Product Name:Human HMGB3 Recombinant Protein
Product Code:RPPB3700
Size:20µg
Species:Human
Target:HMGB3
Synonyms:High Mobility Group Box 3, High-Mobility Group (Nonhistone Chromosomal) Protein 4, Non-Histone Chromosomal Protein, High Mobility Group Protein B3, High Mobility Group Protein 4, HMG-2a, HMG-4.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HMGB3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAKGDPK KPKGKMSAYA FFVQTCREEH KKKNPEVPVN FAEFSKKCSE RWKTMSGKEK SKFDEMAKAD KVRYDREMKD YGPAKGGKKK KDPNAPKRPP SGFFLFCSEF RPKIKSTNPG ISIGDVAKKL GEMWNNLNDS EKQPYITKAA KLKEKYEKDV ADYKSKGKFD GAKGPAKVAR KKV

HMGB3 is a member of the high mobility group (HMG) protein superfamily. HMGB3 holds DNA-binding HMG box domains, as do HMG1 and HMG2, and like the rest of the HMG protein superfamily members has a vital part in DNA replication, transcription and nucleosome assembly.

HMGB3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-180) and having a molecular mass of 22.8kDa.HMGB3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HMGB3: Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: Xq28

Molecular Function:DNA bending activity; double-stranded DNA binding; four-way junction DNA binding; protein binding

Biological Process: DNA geometric change; DNA recombination; multicellular organismal development

Disease: Microphthalmia, Syndromic 13

NCBI Summary:This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:O15347
NCBI GenInfo Identifier:85701353
NCBI Gene ID:3149
NCBI Accession:O15347.4
UniProt Secondary Accession:O15347,O95556, Q6NS40,
UniProt Related Accession:O15347
Molecular Weight:22,980 Da
NCBI Full Name:High mobility group protein B3
NCBI Synonym Full Names:high mobility group box 3
NCBI Official Symbol:HMGB3  
NCBI Official Synonym Symbols:HMG4; HMG-4; HMG2A; HMG-2a  
NCBI Protein Information:high mobility group protein B3
UniProt Protein Name:High mobility group protein B3
UniProt Synonym Protein Names:High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4
Protein Family:High mobility group protein
UniProt Gene Name:HMGB3  
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