Human HMGB3 Recombinant Protein (RPPB3700)
- SKU:
- RPPB3700
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- HMGB3
- Synonyms:
- High Mobility Group Box 3
- High-Mobility Group (Nonhistone Chromosomal) Protein 4
- Non-Histone Chromosomal Protein
- High Mobility Group Protein B3
- Source:
- Escherichia Coli
- Uniprot:
- O15347
Description
| Product Name: | Human HMGB3 Recombinant Protein |
| Product Code: | RPPB3700 |
| Size: | 20µg |
| Species: | Human |
| Target: | HMGB3 |
| Synonyms: | High Mobility Group Box 3, High-Mobility Group (Nonhistone Chromosomal) Protein 4, Non-Histone Chromosomal Protein, High Mobility Group Protein B3, High Mobility Group Protein 4, HMG-2a, HMG-4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The HMGB3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAKGDPK KPKGKMSAYA FFVQTCREEH KKKNPEVPVN FAEFSKKCSE RWKTMSGKEK SKFDEMAKAD KVRYDREMKD YGPAKGGKKK KDPNAPKRPP SGFFLFCSEF RPKIKSTNPG ISIGDVAKKL GEMWNNLNDS EKQPYITKAA KLKEKYEKDV ADYKSKGKFD GAKGPAKVAR KKV |
HMGB3 is a member of the high mobility group (HMG) protein superfamily. HMGB3 holds DNA-binding HMG box domains, as do HMG1 and HMG2, and like the rest of the HMG protein superfamily members has a vital part in DNA replication, transcription and nucleosome assembly.
HMGB3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-180) and having a molecular mass of 22.8kDa.HMGB3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HMGB3: Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq28 Molecular Function:DNA bending activity; double-stranded DNA binding; four-way junction DNA binding; protein binding Biological Process: DNA geometric change; DNA recombination; multicellular organismal development Disease: Microphthalmia, Syndromic 13 |
| NCBI Summary: | This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O15347 |
| NCBI GenInfo Identifier: | 85701353 |
| NCBI Gene ID: | 3149 |
| NCBI Accession: | O15347.4 |
| UniProt Secondary Accession: | O15347,O95556, Q6NS40, |
| UniProt Related Accession: | O15347 |
| Molecular Weight: | 22,980 Da |
| NCBI Full Name: | High mobility group protein B3 |
| NCBI Synonym Full Names: | high mobility group box 3 |
| NCBI Official Symbol: | HMGB3 |
| NCBI Official Synonym Symbols: | HMG4; HMG-4; HMG2A; HMG-2a |
| NCBI Protein Information: | high mobility group protein B3 |
| UniProt Protein Name: | High mobility group protein B3 |
| UniProt Synonym Protein Names: | High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 |
| Protein Family: | High mobility group protein |
| UniProt Gene Name: | HMGB3 |
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