Human HMGB1 Recombinant Protein (RPES2218)

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SKU:
RPES2218
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human HMGB1 Recombinant Protein

High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.

Product Name:Human HMGB1 Recombinant Protein (RPES2218)
Product Code:RPES2218
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:High Mobility Group Protein B1, High Mobility Group Protein 1, HMG-1, HMGB1, HMG1
Accession:P09429
Sequence:Gly2-Phe89
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human HMGB1 is produced by our E.coli expression system and the target gene encoding Gly2-Phe89 is expressed.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:10.5 kDa
AP Mol Mass:14 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 50mMHepes;500mMNaCl;0.5mMDTT; pH7.9 .
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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