Human HMGA2 Recombinant Protein (RPPB3696)

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SKU:
RPPB3696
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HMGA2
Synonyms:
High Mobility Group AT-Hook 2
Synonyms:
HMGIC
Synonyms:
High-Mobility Group(Nonhistone Chromosomal) Protein Isoform I-C
Synonyms:
High Mobility Group AT-HookProtein
Source:
Escherichia Coli
Uniprot:
P52926
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Description

Product Name:Human HMGA2 Recombinant Protein
Product Code:RPPB3696
Size:10µg
Species:Human
Target:HMGA2
Synonyms:High Mobility Group AT-Hook 2, HMGIC, High-Mobility Group(Nonhistone Chromosomal) Protein Isoform I-C, High Mobility Group AT-HookProtein, BABL, HMGI-C, LIPO, STQTL9, High Mobility Group Protein HMGI-C,HMGA2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:HMGA2 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 250mM Imidazole.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH

High Mobility Group AT-Hook 2 (HMGA2) is a member of the non-histone chromosomal high mobility group (HMG) family. HMG proteins perform as architectural factors and are necessary components of the enhancesome. This protein contains structural DNA-binding domains and may function as a transcriptional regulating factor. In addition, identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma proposes a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is implicated in diet-induced obesit. Among the Diseases associated with HMGA2 are diffuse lipomatosis, and 12q14 microdeletion syndrome.

HMGA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids (1-109 a.a) and having a molecular mass of 12.8kDa.HMGA2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; nuclear chromosome; nucleus

Molecular Function:protein binding; nucleosomal DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; DNA bending activity; transcription factor binding

Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription, DNA-dependent; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; chondrocyte differentiation; negative regulation of retroviral genome replication; mitosis; transcription, DNA-dependent; heterochromatin formation; response to virus; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Leiomyoma, Uterine

NCBI Summary:This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P52926
NCBI GenInfo Identifier:1708263
NCBI Gene ID:8091
NCBI Accession:P52926.1
UniProt Related Accession:P52926
Molecular Weight:
NCBI Full Name:High mobility group protein HMGI-C
NCBI Synonym Full Names:high mobility group AT-hook 2
NCBI Official Symbol:HMGA2  
NCBI Official Synonym Symbols:BABL; LIPO; HMGIC; HMGI-C; STQTL9  
NCBI Protein Information:high mobility group protein HMGI-C
UniProt Protein Name:High mobility group protein HMGI-C
UniProt Synonym Protein Names:High mobility group AT-hook protein 2
Protein Family:HMG2-induced ER-remodeling protein
UniProt Gene Name:HMGA2  
UniProt Entry Name:HMGA2_HUMAN
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